3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

BE0000059ProteinHumansHSD3B2

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It is acted on by 8 drugs in DrugBank.

Gene name
HSD3B2
UniProtKB entry
P26439Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
372 residues · 42,052 Da
Also known as
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II · 3-beta-HSD adrenal and gonadal type · 3-beta-HSD II · HSDB3B

Resolves to

Protein
UniProtP26439UniProt name3BHS2_HUMAN
Gene
HGNCHGNC:5218NCBI Gene3284GenBank184401GeneCardsHSD3B2
Pharmacology
KEGGhsa:3284
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, how selective are they, and which programs against it are still in active trials?

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