(R)-Gossypol

DB17379InvestigationalSmall molecule

(R)-Gossypol is the R-isomer of Gossypol.

Mechanism: Pharmacologically active on Bcl-2-like protein 1, Induced myeloid leukemia cell differentiation protein Mcl-1, and Apoptosis regulator Bcl-2
Curator reviewed
Formula / weight: C₃₀H₃₀O₈ · 518.5544 g/mol (avg)
Also known as: (-)-Gossypol · (r)-2,2'-bis(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) · Gossypol r-form · Gossypol, (r)- · Gossypol, r-
Code names: NSC-726190

Resolves to

Compound

Structure

InChIKeyQBKSWRVVCFFDOT-UHFFFAOYSA-NSMILESCC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(=C(C)C=C12)C1=C(O)C2=C(C=C1C)C(C(C)C)=C(O)C(O)=C2C=O

Targets

What you can answer from here — as of September 13, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with (R)-Gossypol, and which of those have an active Phase 3 trial?

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