Serine--tRNA ligase, cytoplasmic

BE0000063ProteinHumansSARS1

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817,... It is acted on by 1 drug in DrugBank.

Gene name
SARS1
UniProtKB entry
P49591Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
514 residues · 58,777 Da
Also known as
6.1.1.11 · SARS · SerRS · SERS · Seryl-tRNA synthetase

Resolves to

Protein
UniProtP49591UniProt nameSYSC_HUMAN
Gene
HGNCHGNC:10537NCBI Gene6301GenBank1050527GeneCardsSARS1
Pharmacology
KEGGhsa:6301
Structure
PDB3VBBPDB4L87PDB4RQE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
16GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
13+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Serine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In