NAV

Serine

Targets (7)Transporters (1)

Identification

Name
Serine
Accession Number
DB00133
Description

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.

Type
Small Molecule
Groups
Investigational, Nutraceutical
Structure
Thumb
3D
Similar Structures
Weight
Average: 105.0926
Monoisotopic: 105.042593095
Chemical Formula
C3H7NO3
Synonyms
  • (S)-2-Amino-3-hydroxypropanoic acid
  • (S)-Serine
  • alpha-Amino-beta-hydroxypropionic acid
  • beta-Hydroxyalanine
  • L-Serine
  • Ser
  • Serina
  • Serine
  • Serinum

Pharmacology

Pharmacology
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Indication

Used as a natural moisturizing agent in some cosmetics and skin care products.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Serine is classified as a nutritionally non-essential amino acid. Serine is critical for the production of the body's proteins, enzymes and muscle tissue. Serine is needed for the proper metabolism of fats and fatty acids. It also helps in the production of antibodies. Serine is used as a natural moisturizing agent in some cosmetics and skin care products. The main source of essential amino acids is from the diet, non-essential amino acids are normally synthesize by humans and other mammals from common intermediates.

Mechanism of action

L-Serine plays a role in cell growth and development (cellular proliferation). The conversion of L-serine to glycine by serine hydroxymethyltransferase results in the formation of the one-carbon units necessary for the synthesis of the purine bases, adenine and guanine. These bases when linked to the phosphate ester of pentose sugars are essential components of DNA and RNA and the end products of energy producing metabolic pathways, ATP and GTP. In addition, L-serine conversion to glycine via this same enzyme provides the one-carbon units necessary for production of the pyrimidine nucleotide, deoxythymidine monophosphate, also an essential component of DNA.

TargetActionsOrganism
UCystathionine beta-synthaseNot AvailableHumans
UL-serine dehydratase/L-threonine deaminaseNot AvailableHumans
USerine racemaseNot AvailableHumans
USerine palmitoyltransferase 2Not AvailableHumans
USerine palmitoyltransferase 1Not AvailableHumans
USerine--tRNA ligase, cytoplasmicNot AvailableHumans
USerine--pyruvate aminotransferaseNot AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Glycine and Serine MetabolismMetabolic
Ammonia RecyclingMetabolic
Selenoamino Acid MetabolismMetabolic
Cystathionine beta-Synthase DeficiencyDisease
Globoid Cell LeukodystrophyDisease
Sarcosine Oncometabolite PathwayDisease
Phosphatidylethanolamine Biosynthesis PE(14:0/14:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/14:1(9Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/15:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/18:1(11Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/18:1(9Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/20:4(8Z,11Z,14Z,17Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/22:1(13Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/22:2(13Z,16Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:0/24:1(15Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/14:1(9Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/18:1(9Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/18:3(6Z,9Z,12Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/18:3(9Z,12Z,15Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/20:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/20:3(8Z,11Z,14Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/20:4(8Z,11Z,14Z,17Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(14:1(9Z)/24:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/14:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/15:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/16:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/18:0)Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/18:1(11Z))Metabolic
Phosphatidylethanolamine Biosynthesis PE(15:0/18:1(9Z))Metabolic
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
2.5% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSerine (125 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Lysine (145 mg) + Leucine (182.5 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Sodium acetate (170 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
2.5%travasol Amino Acid InJ.W.eleC.W.25%dexSerine (125 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Lysine (145 mg) + Leucine (182.5 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Sodium acetate (170 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75% Travas. Amino Acid InJ.W.elecw.25%dexSerine (137.5 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Lysine (159.5 mg) + Leucine (201 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Sodium acetate (215.5 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.Serine (137.5 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (5 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Lysine (159.5 mg) + Leucine (201 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Sodium acetate (215 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-12-311999-08-10Canada flag
20% ProsolSerine (1.02 g) + Alanine (2.76 g) + Arginine (1.96 g) + Aspartic acid (0.6 g) + D-Methionine (0.76 g) + Glutamic acid (1.02 g) + Glycine (2.06 g) + Histidine (1.18 g) + Isoleucine (1.08 g) + L-Lysine (1.35 g) + Leucine (1.08 g) + Methionine (0.76 g) + Phenylalanine (1 g) + Proline (1.34 g) + Threonine (0.98 g) + Tryptophan (0.32 g) + Tyrosine (0.05 g) + Valine (1.44 g)LiquidIntravenousBaxter Laboratories1996-10-09Not applicableCanada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSerine (212.5 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 20% DextroseSerine (212.5 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (20 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 25% DextroseSerine (212.5 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
4.25% Travasol Amino Acid Injection Without Electrlytes In 10% DextroseSerine (212.5 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (10 g) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
4.25% Travasol Amino Acid Injection Without Electrolytes In 20% DextroseSerine (212.5 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (20 g) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ClinimixSerine (1.38 g/1L) + Alanine (5.70 g/1L) + Arginine (3.17 g/1L) + Calcium chloride dihydrate (0.33 g/1L) + D-glucose monohydrate (75.00 g/1L) + Dipotassium phosphate (2.61 g/1L) + Glycine (2.84 g/1L) + Histidine (1.32 g/1L) + Isoleucine (1.65 g/1L) + L-Lysine (2.00 g/1L) + Leucine (2.01 g/1L) + Magnesium chloride hexahydrate (0.51 g/1L) + Methionine (1.10 g/1L) + Phenylalanine (1.54 g/1L) + Proline (1.87 g/1L) + Sodium acetate trihydrate (2.16 g/1L) + Sodium chloride (1.12 g/1L) + Threonine (1.16 g/1L) + Tryptophan (0.50 g/1L) + Tyrosine (0.11 g/1L) + Valine (1.60 g/1L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
ClinimixSerine (1.38 g/1L) + Alanine (5.70 g/1L) + Arginine (3.17 g/1L) + Calcium chloride dihydrate (0.33 g/1L) + D-glucose monohydrate (100.00 g/1L) + Dipotassium phosphate (2.61 g/1L) + Glycine (2.84 g/1L) + Histidine (1.32 g/1L) + Isoleucine (1.65 g/1L) + L-Lysine (2.00 g/1L) + Leucine (2.01 g/1L) + Magnesium chloride hexahydrate (0.51 g/1L) + Methionine (1.10 g/1L) + Phenylalanine (1.54 g/1L) + Proline (1.87 g/1L) + Sodium acetate trihydrate (2.16 g/1L) + Sodium chloride (1.12 g/1L) + Threonine (1.16 g/1L) + Tryptophan (0.50 g/1L) + Tyrosine (0.11 g/1L) + Valine (1.60 g/1L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
ClinimixSerine (4.25 g/2L) + Alanine (17.60 g/2L) + Arginine (9.78 g/2L) + Calcium chloride dihydrate (0.66 g/2L) + D-glucose monohydrate (300.00 g/2L) + Dipotassium phosphate (5.22 g/2L) + Glycine (8.76 g/2L) + Histidine (4.08 g/2L) + Isoleucine (5.10 g/2L) + L-Lysine (4.93 g/2L) + Leucine (6.20 g/2L) + Magnesium chloride hexahydrate (1.02 g/2L) + Methionine (3.40 g/2L) + Phenylalanine (4.76 g/2L) + Proline (5.78 g/2L) + Sodium acetate trihydrate (5.94 g/2L) + Sodium chloride (1.54 g/2L) + Threonine (3.57 g/2L) + Tryptophan (1.53 g/2L) + Tyrosine (0.34 g/2L) + Valine (4.93 g/2L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
PrimeneSerine (1 g/250mL) + Alanine (2 g/250mL) + Arginine (2.1 g/250mL) + Aspartic acid (1.5 g/250mL) + Cysteine (0.47 g/250mL) + Glutamic acid (2.5 g/250mL) + Glycine (1 g/250mL) + Histidine (0.95 g/250mL) + Isoleucine (1.675 g/250mL) + L-Lysine (2.75 g/250mL) + Leucine (2.5 g/250mL) + Methionine (0.6 g/250mL) + Ornithine hydrochloride (0.8 g/250mL) + Phenylalanine (1.05 g/250mL) + Proline (0.75 g/250mL) + Taurine (0.15 g/250mL) + Threonine (0.9 g/250mL) + Tryptophan (0.5 g/250mL) + Tyrosine (0.11 g/250mL) + Valine (1.9 g/250mL)Injection, solutionIntravenousBaxter Healthcare Corporation2017-11-222019-05-31US flag
SynthaminSerine (5 g/1000mL) + Alanine (20.70 g/1000mL) + Arginine (11.50 g/1000mL) + Glycine (10.30 g/1000mL) + Histidine (4.80 g/1000mL) + Isoleucine (6 g/1000mL) + L-Lysine (5.80 g/1000mL) + Leucine (7.30 g/1000mL) + Methionine (4 g/1000mL) + Phenylalanine (5.60 g/1000mL) + Proline (6.80 g/1000mL) + Threonine (4.20 g/1000mL) + Tryptophan (1.80 g/1000mL) + Tyrosine (400 mg/1000mL) + Valine (5.80 g/1000mL)Injection, solutionIntravenousBaxter Healthcare Corporation2017-11-032020-06-30US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as serine and derivatives. These are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Serine and derivatives
Alternative Parents
L-alpha-amino acids / Beta hydroxy acids and derivatives / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Primary alcohols / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives
show 1 more
Substituents
Alcohol / Aliphatic acyclic compound / Alpha-amino acid / Amine / Amino acid / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / Hydroxy acid
show 12 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
proteinogenic amino acid, L-alpha-amino acid, serine, serine family amino acid (CHEBI:17115) / Common amino acids (C00065)

Chemical Identifiers

UNII
452VLY9402
CAS number
56-45-1
InChI Key
MTCFGRXMJLQNBG-REOHCLBHSA-N
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
IUPAC Name
(2S)-2-amino-3-hydroxypropanoic acid
SMILES
N[C@@H](CO)C(O)=O

References

Synthesis Reference

Kenichi Ishiwata, Nobuyoshi Makiguichi, Hideki Kawashima, Tadashi Suzuki, Masami Imadegawa, "Method of producing L-serine." U.S. Patent US4782021, issued August, 1973.

US4782021
General References
Not Available
Human Metabolome Database
HMDB0000187
KEGG Drug
D00016
KEGG Compound
C00065
PubChem Compound
5951
PubChem Substance
46506450
ChemSpider
5736
BindingDB
50357212
RxNav
9671
ChEBI
33384
ChEMBL
CHEMBL11298
ZINC
ZINC000000895034
PharmGKB
PA451330
Guide to Pharmacology
GtP Drug Page
PDBe Ligand
SER
Wikipedia
Serine
MSDS
Download (72.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4TerminatedSupportive CareCancer-related Malnutrition1
4TerminatedSupportive CareIllness, Critical1
4TerminatedSupportive CareParenteral Nutrition (No Primary Condition Studied)1
4WithdrawnSupportive CareMalnutrition1
3CompletedTreatmentGeneral Surgery / Parenteral Feeding1
3CompletedTreatmentGeneral Surgery / Parenteral Nutrition1
3CompletedTreatmentIllness, Critical2
3CompletedTreatmentInfant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Sepsis1
3CompletedTreatmentParents2
3TerminatedTreatmentMalignant Neoplasm of Pancreas1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Spectrum Pharmaceuticals
Dosage Forms
FormRouteStrength
LiquidIntravenous
SyrupOral3.42 g/100ml
Solution / dropsOral1.068 g/30ml
Injection, solutionIntravenous3.75 g/500ml
Injection, solutionIntravenous2.5 g/1000ml
Injection, solutionIntravenous2.5 g/500mL
SolutionIntravenous2.55 g/L
SolutionIntravenous0.61 g/L
SolutionIntravenous1.79 g/L
Injection, solutionIntravenous22.35 g/1000ml
Injection, solutionIntravenous10.5 g/1000ml
SolutionParenteral5.25 g
Injection, solutionIntravenous0.86 g/L
SolutionParenteral2 g
SolutionIntravenous2.453 g
Solution, concentrateIntravenous5 g
SolutionParenteral4.64 g
SolutionIntravenous10.4 g/L
Injection, solutionIntravenous5.82 g/1000ml
Injection, solutionIntravenous
SolutionParenteral14 g
SolutionIntravenous5 g
Injection, solutionIntravenous1.4 g/100ml
SolutionParenteral2.5 g
SolutionIntravenous3.7 g/1000ml
SolutionIntravenous4.15 g
SolutionIntravenous4.15 g/1000ml
SolutionIntravenous1.566 g
SolutionIntraperitoneal951 mg/L
Injection, solutionIntravenous4.02 g/l
Injection, solutionIntravenous5.11 g/l
Injection, solutionIntravenous6.21 g/l
Injection, solutionIntravenous7.3 g/l
Injection, solutionIntravenous12.8 g/1L
Injection, solutionIntravenous4.9 g/1000ml
Injection, solutionIntravenous7.35 g/1500ml
Injection, solutionIntravenous9.8 g/2000ml
Injection, emulsionIntravenous11.41 g/1085ml
Injection, emulsionIntravenous11.41 g/1435ml
Injection, emulsionIntravenous13.17 g/2020ml
Injection, emulsionIntravenous7.08 g/1085ml
Injection, emulsionIntravenous9.46 g/1450ml
EmulsionParenteral3.99 g/1085ml
EmulsionParenteral2.05 g/1085ml
Injection, solutionIntravenous590 mg/100mL
SolutionIntravenous0.69 %
SolutionIntravenous0.59 %
Injection, solutionIntravenous16 g/1000ml
InjectionIntravenous
SolutionIntravenous1.03 g
Injection, emulsionIntravenous
Injection, emulsionIntravenous40 g/1026ml
Injection, emulsionIntravenous467 mg/100mL
Injection, emulsionIntravenous60 g/1540ml
InjectionIntravenous110 g
InjectionIntravenous165 g
InjectionIntravenous220 g
InjectionIntravenous275 g
InjectionIntravenous107 g
InjectionIntravenous143 g
InjectionIntravenous178 g
Injection, emulsionIntravenous10.5 g
Injection, emulsionIntravenous14 g
Injection, emulsionIntravenous2.1 g
Injection, emulsionIntravenous3.1 g
Injection, emulsionIntravenous4.2 g
Injection, emulsionIntravenous7 g
Injection, emulsionIntravenous1.17 g
Injection, emulsionIntravenous1.56 g
Injection, emulsionIntravenous1.755 g
Injection, emulsionIntravenous2.34 g
Injection, emulsionIntravenous3.12 g
Injection, emulsionIntravenous3.51 g
Injection, emulsionIntravenous4.68 g
Injection, solution, concentrateIntravenous
Injection, emulsionParenteral2.33 g
Injection, emulsionIntravenous1.03 g
Injection, emulsionIntravenous1.83 g
EmulsionIntravenous1.83 g
InjectionIntravenous1.03 g
Injection, emulsionIntravenous1.6 g/100mL
Injection, emulsion; injection, solutionIntravenous3.2 g/100mL
EmulsionIntravenous20 mg
EmulsionIntravenous16 g
Injection, emulsionIntravenous3.88 g/1000ml
EmulsionParenteral20 g/l
EmulsionParenteral3.88 g
EmulsionIntravenous88 g
Injection, emulsionIntravenous120 g
Injection, emulsionIntravenous160 g
Injection, emulsionIntravenous4.66 g/1000ml
EmulsionParenteral1.872 g/l
EmulsionParenteral0.222 g
Injection, emulsionIntravenous150 g
Injection, emulsionIntravenous225 g
Injection, emulsionIntravenous300 g
Injection, emulsionIntravenous4.25 g/625ml
EmulsionParenteral6.792 g/l
EmulsionIntravenous6.792 mg
EmulsionIntravenous150 g
EmulsionIntravenous225 g
EmulsionParenteral2.4 g/l
EmulsionParenteral2.88 g/l
EmulsionIntravenous4.656 g
EmulsionParenteral6.792 g
EmulsionIntravenous6.792 g
Injection, solutionIntravenous4.85 g/1000ml
SolutionParenteral0.5 g
Injection, solutionIntravenous11.64 g/2000ml
SolutionParenteral1.56 g
Injection, solution0.6 g/L
SolutionParenteral4.54 g
Solution
Injection, solutionIntraperitoneal95.1 mg/100mL
Injection, solutionIntraperitoneal951 mg/L
LiquidHemodialysis
SolutionParenteral95.1 mg
SolutionIntraperitoneal510 mg/l
EmulsionIntravenous180 g/1250ml
EmulsionIntravenous270 g/1875ml
EmulsionIntravenous90 g/625ml
Injection, emulsionIntravenous120 g/1875ml
Injection, emulsionIntravenous160 g/2500ml
Injection, emulsionIntravenous80 g/1250ml
Injection, emulsionIntravenous150 g/1250ml
Injection, emulsionIntravenous225 g/1875ml
Injection, emulsionIntravenous300 g/2500ml
Injection, emulsionIntravenous180 g/1250ml
Injection, emulsionIntravenous270 g/1875ml
Injection, emulsionIntravenous360 g/2500ml
Injection, emulsionIntravenous11.64 g/2500ml
Injection, emulsionIntravenous5.82 g/1250ml
Injection, emulsionIntravenous8.73 g/1875ml
Injection, emulsionIntravenous90 g/625ml
Injection, emulsionIntravenous12 g/1500ml
Injection, emulsionIntravenous32 g/1000ml
Injection, emulsionIntravenous0.52 g/1000ml
Injection, emulsionIntravenous0.42 g/1000ml
Injection, emulsionIntravenous1.6 g
InjectionIntravenous2.27 g/l
InjectionIntravenous4.12 g/l
EmulsionIntravenous4 g
SolutionIntravenous7.14 g
SolutionIntravenous9.52 g
SolutionIntravenous11.9 g
EmulsionIntravenous6.41 g
EmulsionIntravenous9.61 g
EmulsionIntravenous12.82 g
Injection, emulsionIntravenous6.41 g/1000ml
SolutionIntravenous8.24 g
SolutionIntravenous12.36 g
SolutionIntravenous16.48 g
Injection, emulsionIntravenous8.24 g/1000ml
SolutionParenteral1.48 g/l
Injection, solutionIntravenous0.67 g/100ml
Injection, solutionIntravenous3 g/100ml
EmulsionParenteral1.26 g
EmulsionIntravenous
EmulsionIntravenous3 g
Injection, emulsionIntravenous3.66 g
Injection, emulsionIntravenous5.5 g
Injection, emulsionIntravenous7.33 g
Injection, emulsionIntravenous9.16 g
Injection, emulsionIntravenous3.66 g/1000ml
Injection, solutionIntravenous0.69 %
Injection, solutionIntravenous0.59 %
Injection, solutionIntravenous0.9 %
Injection, solutionIntravenous0.49 %
Injection, solutionIntravenous0.76 %
SolutionIntravenous
SolutionIntravenous3.2 g/100mL
SolutionIntravenous1.6 g/100mL
InjectionIntravenous0.67 g/100ml
SolutionIntravenous800 mg
SolutionParenteral3 g/100ml
Injection, solutionIntravenous7.08 g/1000ml
EmulsionParenteral1.6 g/l
EmulsionParenteral0.66 g/2531ml
EmulsionParenteral0.61 g/l
EmulsionParenteral440 mg
Injection, emulsionIntravenous4.4 g/1000ml
EmulsionParenteral0.71 g
EmulsionParenteral3.1 g
Injection, emulsionIntravenous7.1 g/1000ml
EmulsionParenteral50 g
EmulsionParenteral0.28 g
EmulsionParenteral0.5 g
EmulsionParenteral0.18 g
Injection, solutionIntravenous2.9 g/1000ml
Injection, solutionIntravenous0.76 g/100mL
SolutionIntravenous434 mg
SolutionIntravenous594 mg
EmulsionParenteral18.75 g
EmulsionParenteral0.45 g
SolutionIntravenous12 g/L
SolutionIntravenous16 g/L
SolutionIntravenous5.1 g/16g N
Injection, solutionIntravenous6.3 g/1000ml
EmulsionParenteral2.24 g
EmulsionParenteral4.34 g
EmulsionParenteral3.95 g
EmulsionParenteral7 g
EmulsionParenteral28 g/1000ml
Prices
Unit descriptionCostUnit
L-serine powder3.85USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)228 dec °CPhysProp
water solubility4.25E+005 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-3.07HANSCH,C ET AL. (1995)
pKa2.21 (at 25 °C)KORTUM,G ET AL (1961)
Predicted Properties
PropertyValueSource
Water Solubility480.0 mg/mLALOGPS
logP-3.4ALOGPS
logP-3.9ChemAxon
logS0.66ALOGPS
pKa (Strongest Acidic)2.03ChemAxon
pKa (Strongest Basic)8.93ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity22.04 m3·mol-1ChemAxon
Polarizability9.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9407
Blood Brain Barrier-0.6529
Caco-2 permeable-0.7839
P-glycoprotein substrateNon-substrate0.7693
P-glycoprotein inhibitor INon-inhibitor0.9862
P-glycoprotein inhibitor IINon-inhibitor0.9877
Renal organic cation transporterNon-inhibitor0.9436
CYP450 2C9 substrateNon-substrate0.8673
CYP450 2D6 substrateNon-substrate0.846
CYP450 3A4 substrateNon-substrate0.8389
CYP450 1A2 substrateNon-inhibitor0.9087
CYP450 2C9 inhibitorNon-inhibitor0.9512
CYP450 2D6 inhibitorNon-inhibitor0.9349
CYP450 2C19 inhibitorNon-inhibitor0.945
CYP450 3A4 inhibitorNon-inhibitor0.908
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9914
Ames testNon AMES toxic0.9088
CarcinogenicityNon-carcinogens0.82
BiodegradationReady biodegradable0.9489
Rat acute toxicity1.2700 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9923
hERG inhibition (predictor II)Non-inhibitor0.9811
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.77 KB)
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-0udi-0940000000-59d5e0f76fd204be8110
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-0udi-0980000000-ab49fc3ee88db87d1a16
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS)GC-MSsplash10-0159-0900000000-8e169037bcbe1dcd5de8
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-0uxr-0970000000-67271ed235e35c662db5
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-9540000000-1297bf302358bcf0f1c0
GC-MS Spectrum - GC-MS (3 TMS)GC-MSsplash10-0uxr-1790000000-caaa37778f5a4686f5f0
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0159-0900000000-ae4f860052c41e9ba734
GC-MS Spectrum - EI-BGC-MSsplash10-0uxr-0590000000-ce32a8bfb64d16590b52
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0udi-0940000000-59d5e0f76fd204be8110
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0udi-0980000000-ab49fc3ee88db87d1a16
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0159-0900000000-8e169037bcbe1dcd5de8
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0uxr-0970000000-67271ed235e35c662db5
GC-MS Spectrum - GC-EI-QQGC-MSsplash10-00dr-7966000000-7b5b37fd4ac885548172
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9540000000-1297bf302358bcf0f1c0
GC-MS Spectrum - GC-MSGC-MSsplash10-0uxr-1790000000-caaa37778f5a4686f5f0
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-03di-9100000000-38f84912ebfc7b4e8339
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-03dl-9000000000-89e57995d3ca765a20e8
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-01ox-9100000000-f3baf93032cc9f09cf2d
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0zfr-0900000000-b6085e53e881cdaa1824
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-000i-9000000000-2e16e9d6f9b3c2688f8a
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0a4i-9000000000-9857daa028fb3016a7e2
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0006-0009200000-0617acd25c69bf24ad1f
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0a4i-0900000000-823dfcf6229956372e31
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0a4i-9000000000-eec63565f8a9fe4bd336
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-000i-9000000000-008412efd202c202d56a
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0002-0930000000-932aedc4efb5e1dd5e7b
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0w29-0951000000-cd0895e475dd50e4934d
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-00di-9000000000-15294ba22b153cf5ab5b
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-014i-9000000000-48c370acff657443f0e6
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0udi-0190000000-1bad10ba7388ce0c2249
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0ue9-0792100000-9f2bfe40e4c01044d209
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-00di-9000000000-dfa7aca58cc28303ebc7
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0udi-0900000000-282f31d8021649afdbe8
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0udi-0290000000-eeee98e6b0514b08cd63
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, NegativeLC-MS/MSsplash10-0udi-1900000000-ed66566e27a94ee99f13
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, NegativeLC-MS/MSsplash10-00di-9100000000-b9f6b4b6ee7c88a9c569
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, NegativeLC-MS/MSsplash10-00di-9000000000-929aea63ace0e20c6d43
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, NegativeLC-MS/MSsplash10-00di-9000000000-ba9cd5b3e37ded5d3764
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, PositiveLC-MS/MSsplash10-0a4i-6900000000-5622633ab0a27d2e5360
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, PositiveLC-MS/MSsplash10-03di-9000000000-3e25ca80e2e62be19ac5
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, PositiveLC-MS/MSsplash10-03di-9000000000-5b5167f3e69dd9d329d6
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, PositiveLC-MS/MSsplash10-03dm-9000000000-87d693d73343037f6da8
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, PositiveLC-MS/MSsplash10-0006-9000000000-2347006a6af6d310cb68
MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , PositiveLC-MS/MSsplash10-0a4i-0900000000-5df9317d7fbd63cf5620
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0udi-1900000000-ed66566e27a94ee99f13
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-00di-9100000000-b9f6b4b6ee7c88a9c569
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-00di-9000000000-929aea63ace0e20c6d43
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-00di-9000000000-ba9cd5b3e37ded5d3764
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-00di-9000000000-15294ba22b153cf5ab5b
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-00di-9000000000-dfa7aca58cc28303ebc7
MS/MS Spectrum - , negativeLC-MS/MSsplash10-014i-0900000000-f0c0b4b0e46cc5898d91
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0a4i-6900000000-eadedc5e90cae2073397
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-9000000000-e2ca7435d1b0278f3c4c
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-9000000000-5b5167f3e69dd9d329d6
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03dm-9000000000-87d693d73343037f6da8
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0006-9000000000-2347006a6af6d310cb68
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-2e16e9d6f9b3c2688f8a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-9000000000-9857daa028fb3016a7e2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-9000000000-eec63565f8a9fe4bd336
1H NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Targets

Drugtargets
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Details1. Cystathionine beta-synthase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, th...
Gene Name
CBS
Uniprot ID
P35520
Uniprot Name
Cystathionine beta-synthase
Molecular Weight
60586.05 Da
References
  1. Sen S, Banerjee R: A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer. Biochemistry. 2007 Apr 3;46(13):4110-6. Epub 2007 Mar 13. [PubMed:17352495]
  2. Qu K, Lee SW, Bian JS, Low CM, Wong PT: Hydrogen sulfide: neurochemistry and neurobiology. Neurochem Int. 2008 Jan;52(1-2):155-65. Epub 2007 Jun 8. [PubMed:17629356]
Details2. L-serine dehydratase/L-threonine deaminase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Pyridoxal phosphate binding
Specific Function
Not Available
Gene Name
SDS
Uniprot ID
P20132
Uniprot Name
L-serine dehydratase/L-threonine deaminase
Molecular Weight
34625.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Velayudhan J, Jones MA, Barrow PA, Kelly DJ: L-serine catabolism via an oxygen-labile L-serine dehydratase is essential for colonization of the avian gut by Campylobacter jejuni. Infect Immun. 2004 Jan;72(1):260-8. [PubMed:14688104]
  4. Snell K, Walker DG: Regulation of hepatic L-serine dehydratase and L-serine-pyruvate aminotransferase in the developing neonatal rat. Biochem J. 1974 Dec;144(3):519-31. [PubMed:4377655]
  5. Wong HC, Lessie TG: Hydroxy amino acid metabolism in Pseudomonas cepacia: role of L-serine deaminase in dissimilation of serine, glycine, and threonine. J Bacteriol. 1979 Oct;140(1):240-5. [PubMed:500557]
Details3. Serine racemase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Threonine racemase activity
Specific Function
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Gene Name
SRR
Uniprot ID
Q9GZT4
Uniprot Name
Serine racemase
Molecular Weight
36565.905 Da
References
  1. Fujitani Y, Horiuchi T, Ito K, Sugimoto M: Serine racemases from barley, Hordeum vulgare L., and other plant species represent a distinct eukaryotic group: gene cloning and recombinant protein characterization. Phytochemistry. 2007 Jun;68(11):1530-6. Epub 2007 May 17. [PubMed:17499824]
  2. Ying-Luan Z, Zhao YL, Mori H: [Role of D-serine in the mammalian brain]. Brain Nerve. 2007 Jul;59(7):725-30. [PubMed:17663143]
Details4. Serine palmitoyltransferase 2
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine c-palmitoyltransferase activity
Specific Function
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate ...
Gene Name
SPTLC2
Uniprot ID
O15270
Uniprot Name
Serine palmitoyltransferase 2
Molecular Weight
62923.765 Da
References
  1. Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ: The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. [PubMed:17559874]
Details5. Serine palmitoyltransferase 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine c-palmitoyltransferase activity
Specific Function
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the subst...
Gene Name
SPTLC1
Uniprot ID
O15269
Uniprot Name
Serine palmitoyltransferase 1
Molecular Weight
52743.41 Da
References
  1. Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ: The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. [PubMed:17559874]
Details6. Serine--tRNA ligase, cytoplasmic
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine-trna ligase activity
Specific Function
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into se...
Gene Name
SARS
Uniprot ID
P49591
Uniprot Name
Serine--tRNA ligase, cytoplasmic
Molecular Weight
58776.785 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Zhang Y, Cui J, Zhang R, Wang Y, Hong M: A novel fibrinolytic serine protease from the polychaete Nereis (Neanthes) virens (Sars): purification and characterization. Biochimie. 2007 Jan;89(1):93-103. Epub 2006 Aug 22. [PubMed:16950556]
  4. Follis KE, York J, Nunberg JH: Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical region. Virology. 2005 Oct 10;341(1):122-9. [PubMed:16081124]
  5. McClendon CL, Vaidehi N, Kam VW, Zhang D, Goddard WA 3rd: Fidelity of seryl-tRNA synthetase to binding of natural amino acids from HierDock first principles computations. Protein Eng Des Sel. 2006 May;19(5):195-203. Epub 2006 Mar 3. [PubMed:16517553]
Details7. Serine--pyruvate aminotransferase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transaminase activity
Specific Function
Not Available
Gene Name
AGXT
Uniprot ID
P21549
Uniprot Name
Serine--pyruvate aminotransferase
Molecular Weight
43009.535 Da
References
  1. Ikushiro H, Islam MM, Tojo H, Hayashi H: Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii. J Bacteriol. 2007 Aug;189(15):5749-61. Epub 2007 Jun 8. [PubMed:17557831]
  2. Cowart LA, Hannun YA: Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J Biol Chem. 2007 Apr 20;282(16):12330-40. Epub 2007 Feb 23. [PubMed:17322298]
  3. Son JH, Yoo HH, Kim DH: Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. J Toxicol Environ Health A. 2007 Aug;70(15-16):1310-8. [PubMed:17654249]
  4. Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ: The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. [PubMed:17559874]

Transporters

Details1. Monocarboxylate transporter 10
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
Gene Name
SLC16A10
Uniprot ID
Q8TF71
Uniprot Name
Monocarboxylate transporter 10
Molecular Weight
55492.07 Da
References
  1. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. [PubMed:11278508]

Drug created on June 13, 2005 13:24 / Updated on February 21, 2021 18:50