Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

BE0000072ProteinHumansMCCC2

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. It is acted on by 1 drug in DrugBank.

Gene name
MCCC2
UniProtKB entry
Q9HCC0Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
563 residues · 61,333 Da
Also known as
3-methylcrotonyl-CoA carboxylase 2 · 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit · 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta · 6.4.1.4 · MCCase subunit beta

Resolves to

Protein
UniProtQ9HCC0UniProt nameMCCB_HUMAN
Gene
HGNCHGNC:6937NCBI Gene64087GenBank10934059GeneCardsMCCC2
Pharmacology
KEGGhsa:64087
Structure
PDB8J4ZPDB8J73PDB8J78
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, how selective are they, and which programs against it are still in active trials?

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