Alpha-aminoadipic semialdehyde synthase, mitochondrial

BE0000073ProteinHumansAASS

Bifunctional enzyme that catalyzes the first two steps in lysine degradation. It is acted on by 4 drugs in DrugBank.

Gene name
AASS
UniProtKB entry
Q9UDR5Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
926 residues · 102,131 Da
Also known as
LKR/SDH

Resolves to

Protein
UniProtQ9UDR5UniProt nameAASS_HUMAN
Gene
HGNCHGNC:17366NCBI Gene10157GenBank7264724GeneCardsAASS
Pharmacology
KEGGhsa:10157
Structure
PDB5L76PDB5L78PDB5O1N
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-aminoadipic semialdehyde synthase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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