Nuclear receptor subfamily 0 group B member 1

BE0000074ProteinHumansNR0B1

Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:12482977, PubMed:32433991). It is acted on by 2 drugs in DrugBank.

Gene name
NR0B1
UniProtKB entry
P51843Swiss-Prot
Cellular location
Nucleus
Residues / weight
470 residues · 51,717 Da
Also known as
AHC · DAX1 · DSS-AHC critical region on the X chromosome protein 1 · Nuclear receptor DAX-1

Resolves to

Protein
UniProtP51843UniProt nameNR0B1_HUMAN
Gene
HGNCHGNC:7960NCBI Gene190GenBank786532GeneCardsNR0B1
Pharmacology
KEGGhsa:190
Structure
PDB4RWV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear receptor subfamily 0 group B member 1, how selective are they, and which programs against it are still in active trials?

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