Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

BE0000087ProteinHumansPLOD1

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
PLOD1
UniProtKB entry
Q02809Swiss-Prot
Cellular location
Rough endoplasmic reticulum membrane
Residues / weight
727 residues · 83,550 Da
Also known as
1.14.11.4 · LH1 · LLH · Lysyl hydroxylase 1 · PLOD

Resolves to

Protein
UniProtQ02809UniProt namePLOD1_HUMAN
Gene
HGNCHGNC:9081NCBI Gene5351GenBank190074GeneCardsPLOD1
Pharmacology
KEGGhsa:5351
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, how selective are they, and which programs against it are still in active trials?

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