Pyruvate kinase PKM

BE0000088ProteinHumansPKM

Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). It is acted on by 12 drugs in DrugBank.

Gene name
PKM
UniProtKB entry
P14618Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
531 residues · 57,936 Da
Also known as
2.7.1.40 · CTHBP · Cytosolic thyroid hormone-binding protein · OIP-3 · OIP3

Resolves to

Protein
UniProtP14618UniProt nameKPYM_HUMAN
Gene
HGNCHGNC:9021NCBI Gene5315GenBank189998GeneCardsPKM
Pharmacology
IUPHAR/GtoPdb3006KEGGhsa:5315
Structure
PDB1T5APDB1ZJHPDB3BJF
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate kinase PKM, how selective are they, and which programs against it are still in active trials?

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