DNA topoisomerase I, mitochondrial

BE0000091ProteinHumansTOP1MT

Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. It is acted on by 2 drugs in DrugBank.

Gene name
TOP1MT
UniProtKB entry
Q969P6Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
601 residues · 69,871 Da
Also known as
5.6.2.1 · TOP1mt

Resolves to

Protein
UniProtQ969P6UniProt nameTOP1M_HUMAN
Gene
HGNCHGNC:29787NCBI Gene116447GenBank15919359GeneCardsTOP1MT
Pharmacology
KEGGhsa:116447
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase I, mitochondrial, how selective are they, and which programs against it are still in active trials?

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