Alanine--glyoxylate aminotransferase 2, mitochondrial

BE0000102ProteinHumansAGXT2

Multifunctional aminotransferase with a broad substrate specificity (PubMed:20018850, PubMed:23023372, PubMed:24586340). It is acted on by 4 drugs in DrugBank.

Gene name
AGXT2
UniProtKB entry
Q9BYV1Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
514 residues · 57,156 Da
Also known as
(R)-3-amino-2-methylpropionate--pyruvate transaminase · 2.6.1.44 · AGT 2 · AGT2 · Beta-ALAAT II

Resolves to

Protein
UniProtQ9BYV1UniProt nameAGT2_HUMAN
Gene
HGNCHGNC:14412NCBI Gene64902GenBank12406973GeneCardsAGXT2
Pharmacology
KEGGhsa:64902
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alanine--glyoxylate aminotransferase 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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