Peptidoglycan D,D-transpeptidase MrdA

BE0000103ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)mrdA

Catalyzes cross-linking of the peptidoglycan cell wall. It is acted on by 1 drug in DrugBank.

Gene name
mrdA
UniProtKB entry
P44469Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
651 residues · 73,812 Da
Also known as
3.4.16.4 · PBP-2 · pbp2 · Penicillin-binding protein 2

Resolves to

Protein
UniProtP44469UniProt nameMRDA_HAEIN
Gene
NCBI Gene950929GenBank1572976
Pharmacology
KEGGhin:HI0032
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase MrdA, how selective are they, and which programs against it are still in active trials?

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