P2Y purinoceptor 12

BE0000110ProteinHumansP2RY12

Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. It is acted on by 13 drugs in DrugBank.

Gene name
P2RY12
UniProtKB entry
Q9H244Swiss-Prot
Cellular location
Cell membrane
Residues / weight
342 residues · 39,438 Da
Also known as
ADP-glucose receptor · ADPG-R · HORK3 · P2T(AC) · P2Y(AC)

Resolves to

Protein
UniProtQ9H244UniProt nameP2Y12_HUMAN
Gene
HGNCHGNC:18124NCBI Gene64805GenBank12083902GeneCardsP2RY12
Pharmacology
IUPHAR/GtoPdb328KEGGhsa:64805
Structure
PDB4NTJPDB4PXZPDB4PY0
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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42Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on P2Y purinoceptor 12, how selective are they, and which programs against it are still in active trials?

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