Prostacyclin synthase

BE0000117ProteinHumansPTGIS

Catalyzes the biosynthesis and metabolism of eicosanoids. It is acted on by 3 drugs in DrugBank.

Gene name
PTGIS
UniProtKB entry
Q16647Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
500 residues · 57,103 Da
Also known as
5.3.99.4 · CYP8 · CYP8A1 · Hydroperoxy icosatetraenoate dehydratase · Prostaglandin I2 synthase

Resolves to

Protein
UniProtQ16647UniProt namePTGIS_HUMAN
Gene
HGNCHGNC:9603NCBI Gene5740GenBank10944956GeneCardsPTGIS
Pharmacology
IUPHAR/GtoPdb1356KEGGhsa:5740
Structure
PDB2IAGPDB3B6H
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostacyclin synthase, how selective are they, and which programs against it are still in active trials?

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