Phenylbutazone

DB00812ApprovedVet approvedWithdrawnSmall molecule

Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. A drug that has anti-inflammatory, antipyretic, and analgesic activities.

Mechanism: Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Curator reviewed
Primary indication: For the treatment of backache and ankylosing spondylitisCurator reviewed · 3 structured indications
Formula / weight: C₁₉H₂₀N₂O₂ · 308.3743 g/mol (avg)
First approval: Canada, 1974
Also known as: Phenbutazone
Code names: G-13871 · NSC-25134 · USAF Ge-15

Resolves to

Compound

UNIIGN5P7K3T8SCAS50-33-9ChEMBLCHEMBL101ChEBI48574PubChem4781KEGGD00510

Clinical / RWD

RxNorm8160ATCM01AA01ATCM01BA01ATCM02AA01PharmGKBPA450932

Structure

InChIKeyVYMDGNCVAMGZFE-UHFFFAOYSA-NSMILESCCCCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1

Targets

P23219PTGS1P35354PTGS2Q16647PTGIS

Transporters

Q4U2R8SLC22A6Q8TCC7SLC22A8Q9NSA0SLC22A11

What you can answer from here — as of September 23, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3TransportersSubstrate / inhibitor direction, not just membership

Listed above

1,713Drug interactionsStructured to mechanism, not free text

3Structured indicationsCondition, population, route and combination as fields, not prose

4ContraindicationsEach with its own population and attribute set

21Marketed productsAcross 4 countries and 17 labellers

3ATC codesIncluding every combination product, plus 31 drug categories

22+ReferencesStructured and connected to the statements they support

Which drugs share a target with Phenylbutazone, and which of those have an active Phase 3 trial?

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