Dihydropteroate synthase type-1
Details
- Name
- Dihydropteroate synthase type-1
- Kind
- protein
- Synonyms
- 2.5.1.15
- DHPS
- Dihydropteroate pyrophosphorylase type I
- Dihydropteroate synthase type I
- suf3
- Gene Name
- sulI
- UniProtKB Entry
- Q49184Swiss-Prot
- Organism
- Mycobacterium fortuitum
- NCBI Taxonomy ID
- 1766
- Amino acid sequence
>lcl|BSEQ0010168|Dihydropteroate synthase type-1 MLRSRVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPV SPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIA EADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGM GFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELH AIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA
- Number of residues
- 283
- Molecular Weight
- 30638.43
- Theoretical pI
- 6.52
- GO Classification
- Functionsdihydropteroate synthase activity / metal ion bindingProcessesfolic acid biosynthetic process / response to antibiotic / tetrahydrofolate biosynthetic process
- General Function
- Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). Implicated in resistance to sulfonamide (PubMed:2163027).
- Specific Function
- dihydropteroate synthase activity
- Pfam Domain Function
- Pterin_bind (PF00809)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0000239|852 bp ATGTTACGCAGCAGGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTC GATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGA GTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTA TCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATG CACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGC GTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCT GAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGC ACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGG GTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTCGATCCGGGGATG GGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAG CTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGC GCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCAC GCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCA ATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTA GATCATGCCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q49184 UniProtKB Entry Name DHP1_MYCFO GenBank Protein ID 44284 GenBank Gene ID X53635 - General References
- Martin C, Timm J, Rauzier J, Gomez-Lus R, Davies J, Gicquel B: Transposition of an antibiotic resistance element in mycobacteria. Nature. 1990 Jun 21;345(6277):739-43. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Sulfapyridine approved unknown target inhibitor Details