Dihydropteroate synthase type-1

BE0000120ProteinMycobacterium fortuitumsulI

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
sulI
UniProtKB entry
Q49184Swiss-Prot
Residues / weight
283 residues · 30,638 Da
Also known as
2.5.1.15 · DHPS · Dihydropteroate pyrophosphorylase type I · Dihydropteroate synthase type I · suf3

Resolves to

Protein
UniProtQ49184UniProt nameDHP1_MYCFO
Gene
GenBank44284
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydropteroate synthase type-1, how selective are they, and which programs against it are still in active trials?

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