Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. Antibacterial, potentially toxic, and previously used to treat certain skin diseases.
- Mechanism
- Curator reviewed
Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.
- Primary indication
- For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosumCurator reviewed
- Formula / weight
- C11H11N3O2S · 249.289 g/mol (avg)
- First approval
- Canada, 2000
- Also known as
- 2-Sulfanilamidopyridine · 2-Sulfanilylaminopyridine · 2-Sulfapyridine · N(1)-Pyridylsulfanilamide · Sulphapyridine
- Code names
- M & B 693 · N000159
Resolves to
GECHUMIMRBOMGK-UHFFFAOYSA-NSMILESNC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=N1What you can answer from here — as of September 12, 2026
Which drugs share a target with Sulfapyridine, and which of those have an active Phase 3 trial?
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