Interleukin-3

BE0000125ProteinHumansIL3

Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). It is acted on by 6 drugs in DrugBank.

Gene name
IL3
UniProtKB entry
P08700Swiss-Prot
Cellular location
Secreted
Residues / weight
152 residues · 17,233 Da
Also known as
Hematopoietic growth factor · IL-3 · Mast cell growth factor · MCGF · Multipotential colony-stimulating factor

Resolves to

Protein
UniProtP08700UniProt nameIL3_HUMAN
Gene
HGNCHGNC:6011NCBI Gene3562GenBank307059GeneCardsIL3
Pharmacology
KEGGhsa:3562
Structure
PDB1JLIPDB5UV8PDB5UWC
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-3, how selective are they, and which programs against it are still in active trials?

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