Alpha-aminoadipic semialdehyde dehydrogenase

BE0000135ProteinHumansALDH7A1

Aldehyde dehydrogenase enzyme that mediates important protective effects (PubMed:16491085, PubMed:20207735, PubMed:20554659, PubMed:21338592, PubMed:25554827, PubMed:31302938, PubMed:31652343, PubMed:38604394, PubMed:40233740). It is acted on by 2 drugs in DrugBank.

Gene name
ALDH7A1
UniProtKB entry
P49419Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
539 residues · 58,487 Da
Also known as
1.2.1.31 · Aldehyde dehydrogenase family 7 member A1 · Alpha-AASA dehydrogenase · Antiquitin-1 · ATQ1

Resolves to

Protein
UniProtP49419UniProt nameAL7A1_HUMAN
Gene
HGNCHGNC:877NCBI Gene501GenBank797410GeneCardsALDH7A1
Pharmacology
KEGGhsa:501
Structure
PDB2J6LPDB4X0TPDB4X0U
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-aminoadipic semialdehyde dehydrogenase, how selective are they, and which programs against it are still in active trials?

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