Mitochondrial inner membrane m-AAA protease component AFG3L2

BE0000139ProteinHumansAFG3L2

Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:19748354, PubMed:28396416, PubMed:29932645, PubMed:30683687, PubMed:31327635, PubMed:37917749,... It is acted on by 1 drug in DrugBank.

Gene name
AFG3L2
UniProtKB entry
Q9Y4W6Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
797 residues · 88,583 Da
Also known as
3.4.24.- · 3.6.-.- · AFG3-like protein 2 · Paraplegin-like protein

Resolves to

Protein
UniProtQ9Y4W6UniProt nameAFG32_HUMAN
Gene
HGNCHGNC:315NCBI Gene10939GenBank5457357GeneCardsAFG3L2
Pharmacology
KEGGhsa:10939
Structure
PDB2LNAPDB6NYY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mitochondrial inner membrane m-AAA protease component AFG3L2, and which indications are they being tested in?

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