Solute carrier family 12 member 6

BE0000140ProteinHumansSLC12A6

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). It is acted on by 1 drug in DrugBank.

Gene name
SLC12A6
UniProtKB entry
Q9UHW9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,150 residues · 127,616 Da
Also known as
Electroneutral potassium-chloride cotransporter 3 · K-Cl cotransporter 3 · KCC3

Resolves to

Protein
UniProtQ9UHW9UniProt nameS12A6_HUMAN
Gene
HGNCHGNC:10914NCBI Gene9990GenBank6693798GeneCardsSLC12A6
Pharmacology
KEGGhsa:9990
Structure
PDB6M1YPDB6M22PDB6Y5R
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 6, how selective are they, and which programs against it are still in active trials?

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