Cysteine desulfurase

BE0000151ProteinHumansNFS1

Cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at... It is acted on by 3 drugs in DrugBank.

Gene name
NFS1
UniProtKB entry
Q9Y697Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
457 residues · 50,195 Da
Also known as
2.8.1.7 · NIFS

Resolves to

Protein
UniProtQ9Y697UniProt nameNFS1_HUMAN
Gene
HGNCHGNC:15910NCBI Gene9054GenBank24042327GeneCardsNFS1
Pharmacology
KEGGhsa:9054
Structure
PDB5KZ5PDB5USRPDB5WGB
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cysteine desulfurase, how selective are they, and which programs against it are still in active trials?

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