Thiamine pyrophosphokinase 1

BE0000157ProteinHumansTPK1

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism (PubMed:38547260). It is acted on by 2 drugs in DrugBank.

Gene name
TPK1
UniProtKB entry
Q9H3S4Swiss-Prot
Residues / weight
243 residues · 27,265 Da
Also known as
2.7.6.- · hTPK1 · Placental protein 20 · PP20 · Thiamin pyrophosphokinase 1

Resolves to

Protein
UniProtQ9H3S4UniProt nameTPK1_HUMAN
Gene
HGNCHGNC:17358NCBI Gene27010GenBank12248915GeneCardsTPK1
Pharmacology
KEGGhsa:27010
Structure
PDB3S4YPDB9HJC
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thiamine pyrophosphokinase 1, how selective are they, and which programs against it are still in active trials?

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