Biotin--protein ligase

BE0000159ProteinHumansHLCS

Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. It is acted on by 1 drug in DrugBank.

Gene name
HLCS
UniProtKB entry
P50747Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
726 residues · 80,759 Da
Also known as
6.3.4.- · Biotin apo-protein ligase

Resolves to

Protein
UniProtP50747UniProt nameBPL1_HUMAN
Gene
HGNCHGNC:4976NCBI Gene3141GenBank577625GeneCardsHLCS
Pharmacology
KEGGhsa:3141
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Biotin--protein ligase, how selective are they, and which programs against it are still in active trials?

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