2-oxoglutarate dehydrogenase complex component E1

BE0000162ProteinHumansOGDH

2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). It is acted on by 6 drugs in DrugBank.

Gene name
OGDH
UniProtKB entry
Q02218Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
1,023 residues · 115,934 Da
Also known as
1.2.4.2 · 2-oxoglutarate dehydrogenase, mitochondrial · Alpha-ketoglutarate dehydrogenase · Alpha-KGDH-E1 · E1o

Resolves to

Protein
UniProtQ02218UniProt nameODO1_HUMAN
Gene
HGNCHGNC:8124NCBI Gene4967GenBank531241GeneCardsOGDH
Pharmacology
KEGGhsa:4967
Structure
PDB3ERYPDB7WGRPDB8I0K
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-oxoglutarate dehydrogenase complex component E1, how selective are they, and which programs against it are still in active trials?

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