L-serine dehydratase/L-threonine deaminase

BE0000164ProteinHumansSDS

Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively. It is acted on by 2 drugs in DrugBank.

Gene name
SDS
UniProtKB entry
P20132Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
328 residues · 34,625 Da
Also known as
4.3.1.17 · Hepatic serine dehydratase · hSDH · L-serine deaminase · L-threonine dehydratase

Resolves to

Protein
UniProtP20132UniProt nameSDHL_HUMAN
Gene
HGNCHGNC:10691NCBI Gene10993GenBank338030GeneCardsSDS
Pharmacology
KEGGhsa:10993
Structure
PDB1P5JPDB4H27
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on L-serine dehydratase/L-threonine deaminase, how selective are they, and which programs against it are still in active trials?

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