Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

BE0000176ProteinHumansSDHA

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). It is acted on by 6 drugs in DrugBank.

Gene name
SDHA
UniProtKB entry
P31040Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
664 residues · 72,691 Da
Also known as
1.3.5.1 · Flavoprotein subunit of complex II · Fp · Malate dehydrogenase [quinone] flavoprotein subunit · SDH2

Resolves to

Protein
UniProtP31040UniProt nameSDHA_HUMAN
Gene
HGNCHGNC:10680NCBI Gene6389GenBank506338GeneCardsSDHA
Pharmacology
KEGGhsa:6389
Structure
PDB6VAXPDB8DYDPDB8DYE
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, how selective are they, and which programs against it are still in active trials?

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