Pyridoxine-5'-phosphate oxidase

BE0000181ProteinHumansPNPO

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). It is acted on by 4 drugs in DrugBank.

Gene name
PNPO
UniProtKB entry
Q9NVS9Swiss-Prot
Residues / weight
261 residues · 29,988 Da
Also known as
1.4.3.5 · Pyridoxamine-phosphate oxidase

Resolves to

Protein
UniProtQ9NVS9UniProt namePNPO_HUMAN
Gene
HGNCHGNC:30260NCBI Gene55163GenBank21728336GeneCardsPNPO
Pharmacology
KEGGhsa:55163
Structure
PDB1NRGPDB3HY8PDB6H00
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyridoxine-5'-phosphate oxidase, how selective are they, and which programs against it are still in active trials?

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