NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

BE0000191ProteinHumansNDUFS3

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060). It is acted on by 2 drugs in DrugBank.

Gene name
NDUFS3
UniProtKB entry
O75489Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
264 residues · 30,241 Da
Also known as
7.1.1.2 · CI-30kD · Complex I-30kD · NADH-ubiquinone oxidoreductase 30 kDa subunit

Resolves to

Protein
UniProtO75489UniProt nameNDUS3_HUMAN
Gene
HGNCHGNC:7710NCBI Gene4722GenBank3337441GeneCardsNDUFS3
Pharmacology
KEGGhsa:4722
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial, how selective are they, and which programs against it are still in active trials?

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