DNA ligase 1

BE0000199ProteinHumansLIG1

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). It is acted on by 2 drugs in DrugBank.

Gene name
LIG1
UniProtKB entry
P18858Swiss-Prot
Cellular location
Nucleus
Residues / weight
919 residues · 101,735 Da
Also known as
6.5.1.1 · DNA ligase I · Polydeoxyribonucleotide synthase [ATP] 1

Resolves to

Protein
UniProtP18858UniProt nameDNLI1_HUMAN
Gene
HGNCHGNC:6598NCBI Gene3978GenBank187143GeneCardsLIG1
Pharmacology
KEGGhsa:3978
Structure
PDB1X9NPDB5YY9PDB6P09
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA ligase 1, how selective are they, and which programs against it are still in active trials?

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