Valine--tRNA ligase

BE0000223ProteinHumansVARS1

Catalyzes the attachment of valine to tRNA(Val). It is acted on by 1 drug in DrugBank.

Gene name
VARS1
UniProtKB entry
P26640Swiss-Prot
Residues / weight
1,264 residues · 140,475 Da
Also known as
6.1.1.9 · G7A · Protein G7a · ValRS · Valyl-tRNA synthetase

Resolves to

Protein
UniProtP26640UniProt nameSYVC_HUMAN
Gene
HGNCHGNC:12651NCBI Gene7407GenBank31545GeneCardsVARS1
Pharmacology
KEGGhsa:7407
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Valine--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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