Threonine--tRNA ligase 1, cytoplasmic

BE0000234ProteinHumansTARS1

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). It is acted on by 2 drugs in DrugBank.

Gene name
TARS1
UniProtKB entry
P26639Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
723 residues · 83,435 Da
Also known as
6.1.1.3 · TARS · Threonyl-tRNA synthetase · Threonyl-tRNA synthetase 1 · ThrRS

Resolves to

Protein
UniProtP26639UniProt nameSYTC_HUMAN
Gene
HGNCHGNC:11572NCBI Gene6897GenBank1464742GeneCardsTARS1
Pharmacology
KEGGhsa:6897
Structure
PDB1WWTPDB4HWTPDB4P3N
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Threonine--tRNA ligase 1, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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