Sodium- and chloride-dependent GABA transporter 1

BE0000249ProteinHumansSLC6A1

Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). It is acted on by 5 drugs in DrugBank.

Gene name
SLC6A1
UniProtKB entry
P30531Swiss-Prot
Cellular location
Cell membrane
Residues / weight
599 residues · 67,073 Da
Also known as
GABATR · GABT1 · GAT-1 · GAT1 · Solute carrier family 6 member 1

Resolves to

Protein
UniProtP30531UniProt nameSC6A1_HUMAN
Gene
HGNCHGNC:11042NCBI Gene6529GenBank31658GeneCardsSLC6A1
Pharmacology
IUPHAR/GtoPdb929KEGGhsa:6529
Structure
PDB7SK2PDB7Y7VPDB7Y7W
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium- and chloride-dependent GABA transporter 1, how selective are they, and which programs against it are still in active trials?

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