Guvacine

DB08848ExperimentalSmall molecule

Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being... Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine.

Mechanism: Experimental studies are still being investigated to determine the exact mechanisms of action of guvacine. What is known is that guvacine binds selectively to presynaptic GABA reuptake transporters and prevents the reuptake of GABA, but has no affinity for GABA postsynaptic receptors.
Curator reviewed
Primary indication: There is no approved indication for guvacine.Curator reviewed
Formula / weight: C₆H₉NO₂ · 127.1412 g/mol (avg)

Resolves to

Compound

UNII41538P325KCAS498-96-4ChEMBLCHEMBL76768ChEBI5576PubChem3532KEGGC10149

Structure

InChIKeyQTDZOWFRBNTPQR-UHFFFAOYSA-NSMILESOC(=O)C1=CCCNC1

Targets

Q9NSD5SLC6A13P30531SLC6A1P48066SLC6A11P48065SLC6A12

What you can answer from here — as of August 30, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

16+ReferencesStructured and connected to the statements they support

Which drugs share a target with Guvacine, and which of those have an active Phase 3 trial?

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