Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Details
- Name
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Kind
- protein
- Synonyms
- NMDMC
- Gene Name
- MTHFD2
- UniProtKB Entry
- P13995Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000535|Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
- Number of residues
- 350
- Molecular Weight
- 37894.775
- Theoretical pI
- 9.12
- GO Classification
- Processesfolic acid metabolic process / tetrahydrofolate interconversionComponentsmitochondrial matrix
- General Function
- Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency
- Specific Function
- magnesium ion binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0010228|Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) ATGGCTGCGACTTCTCTAATGTCTGCTTTGGCTGCCCGGCTGCTGCAGCCCGCGCACAGC TGCTCCCTTCGCCTTCGCCCTTTCCACCTCGCGGCAGTTCGAAATGAAGCTGTTGTCATT TCTGGAAGGAAACTGGCCCAGCAGATCAAGCAGGAAGTGCGGCAGGAGGTAGAAGAGTGG GTGGCCTCAGGCAACAAACGGCCACACCTGAGTGTGATCCTGGTTGGCGAGAATCCTGCA AGTCACTCCTATGTCCTCAACAAAACCAGGGCAGCTGCAGTTGTGGGAATCAACAGTGAG ACAATTATGAAACCAGCTTCAATTTCAGAGGAAGAATTGTTGAATTTAATCAATAAACTG AATAATGATGATAATGTAGATGGCCTCCTTGTTCAGTTGCCTCTTCCAGAGCATATTGAT GAGAGAAGGATCTGCAATGCTGTTTCTCCAGACAAGGATGTTGATGGCTTTCATGTAATT AATGTAGGACGAATGTGTTTGGATCAGTATTCCATGTTACCGGCTACTCCATGGGGTGTG TGGGAAATAATCAAGCGAACTGGCATTCCAACCCTAGGGAAGAATGTGGTTGTGGCTGGA AGGTCAAAAAACGTTGGAATGCCCATTGCAATGTTACTGCACACAGATGGGGCGCATGAA CGTCCCGGAGGTGATGCCACTGTTACAATATCTCATCGATATACTCCCAAAGAGCAGTTG AAGAAACATACAATTCTTGCAGATATTGTAATATCTGCTGCAGGTATTCCAAATCTGATC ACAGCAGATATGATCAAGGAAGGAGCAGCAGTCATTGATGTGGGAATAAATAGAGTTCAC GATCCTGTAACTGCCAAACCCAAGTTGGTTGGAGATGTGGATTTTGAAGGAGTCAGACAA AAAGCTGGGTATATCACTCCAGTTCCTGGAGGTGTTGGCCCCATGACAGTGGCAATGCTA ATGAAGAATACCATTATTGCTGCAAAAAAGGTGCTGAGGCTTGAAGAGCGAGAAGTGCTG AAGTCTAAAGAGCTTGGGGTAGCCACTAATTAA
- Chromosome Location
- 2
- Locus
- 2p13.1
- External Identifiers
Resource Link UniProtKB ID P13995 UniProtKB Entry Name MTDC_HUMAN GenBank Protein ID 35071 GenBank Gene ID X16396 GeneCard ID MTHFD2 GenAtlas ID MTHFD2 HGNC ID HGNC:7434 PDB ID(s) 5TC4, 6JIB, 6JID, 6KG2, 6S4A, 6S4E, 6S4F, 7EHJ, 7EHM, 7EHN, 7EHV KEGG ID hsa:10797 NCBI Gene ID 10797 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tetrahydrofolic acid nutraceutical unknown target cofactor Details NADH approved, nutraceutical unknown target Details