Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

BE0000268ProteinHumansMTHFD2

Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. It is acted on by 2 drugs in DrugBank.

Gene name
MTHFD2
UniProtKB entry
P13995Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
350 residues · 37,895 Da
Also known as
NMDMC

Resolves to

Protein
UniProtP13995UniProt nameMTDC_HUMAN
Gene
HGNCHGNC:7434NCBI Gene10797GenBank35071GeneCardsMTHFD2
Pharmacology
KEGGhsa:10797
Structure
PDB5TC4PDB6JIBPDB6JID
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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