Tetrahydrofolic acid is a folic acid derivative that is produced from dihydrofolic acid after conversion by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a soluble... It is a soluble coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.
- Mechanism
- Curator reviewed
Tetrahydrofolate is transported across cells by receptor-mediated endocytosis where it is needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate.
- Primary indication
- For nutritional supplementation, also for treating dietary shortage or imbalance.Curator reviewed
- Formula / weight
- C19H23N7O6 · 445.4292 g/mol (avg)
- Also known as
- Tetrahydrofolate
Resolves to
MSTNYGQPCMXVAQ-KIYNQFGBSA-NSMILESNC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1What you can answer from here — as of September 12, 2026
Which drugs share a target with Tetrahydrofolic acid, and which of those have an active Phase 3 trial?
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