Solute carrier family 12 member 7

BE0000276ProteinHumansSLC12A7

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). It is acted on by 1 drug in DrugBank.

Gene name
SLC12A7
UniProtKB entry
Q9Y666Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,083 residues · 119,105 Da
Also known as
Electroneutral potassium-chloride cotransporter 4 · K-Cl cotransporter 4 · KCC4

Resolves to

Protein
UniProtQ9Y666UniProt nameS12A7_HUMAN
Gene
HGNCHGNC:10915NCBI Gene10723GenBank5106521GeneCardsSLC12A7
Pharmacology
KEGGhsa:10723
Structure
PDB7D99
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 7, how selective are they, and which programs against it are still in active trials?

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