Chronophin

BE0000278ProteinHumansPDXP

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role... It is acted on by 2 drugs in DrugBank.

Gene name
PDXP
UniProtKB entry
Q96GD0Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
296 residues · 31,698 Da
Also known as
3.1.3.16 · 3.1.3.74 · CIN · PLP · PLP phosphatase

Resolves to

Protein
UniProtQ96GD0UniProt namePLPP_HUMAN
Gene
HGNCHGNC:30259NCBI Gene57026GenBank37545684GeneCardsPDXP
Pharmacology
KEGGhsa:57026
Structure
PDB2CFRPDB2CFSPDB2CFT
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Chronophin, how selective are they, and which programs against it are still in active trials?

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