Identification

Name
Pyridoxine
Accession Number
DB00165
Description

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are able to synthesize pyridoxine through endogenous biological processes, animals must obtain it through their diet.

More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. It's important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5'-phosphate, pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine 1.

Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA) 2.

Pyridoxine is used medically for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy (due to Isoniazid's mechanism of action which competitively inhibits the action of pyridoxine in the above-mentioned metabolic functions). It is also used in combination with Doxylamine (as the commercially available product Diclectin) for the treatment of nausea and vomiting in pregnancy.

Type
Small Molecule
Groups
Approved, Investigational, Nutraceutical, Vet approved
Structure
Thumb
Weight
Average: 169.1778
Monoisotopic: 169.073893223
Chemical Formula
C8H11NO3
Synonyms
  • 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
  • 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
  • 3-hydroxy-4,5-dimethylol-α-picoline
  • 5-hydroxy-6-methyl-3,4-pyridinedimethanol
  • Piridoxina
  • Pyridoxine
  • Pyridoxinum
  • Pyridoxol
  • Vitamin B6

Pharmacology

Indication

Pyridoxine is indicated for the treatment of vitamin B6 deficiency and for the prophylaxis of Isoniazid-induced peripheral neuropathy. It is also approved by Health Canada for the treatment of nausea and vomiting in pregnancy in a combination product with Doxylamine (as the commercially available product Diclectin).

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.

Mechanism of action

Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).

TargetActionsOrganism
APyridoxal kinase
ligand
Humans
Absorption

The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum. The Cmax of pyridoxine is achieved within 5.5 hours.

Volume of distribution

Pyridoxine main active metabolite, pyridoxal 5’-phosphate, is released into the circulation (accounting for at least 60% of circulating vitamin B6) and is highly protein bound, primarily to albumin.

Protein binding

Pyridoxine main active metabolite, pyridoxal 5’-phosphate, is released into the circulation (accounting for at least 60% of circulating vitamin B6) and is highly protein bound, primarily to albumin.

Metabolism

Pyridoxine is a prodrug primarily metabolized in the liver. The metabolic scheme for pyridoxine is complex, with formation of primary and secondary metabolites along with interconversion back to pyridoxine. Pyridoxine's major metabolite is 4-pyridoxic acid.

Route of elimination

The major metabolite of pyridoxine, 4-pyridoxic acid, is inactive and is excreted in urine

Half-life

The total adult body pool consists of 16 to 25 mg of pyridoxine. Its half-life appears to be 15 to 20 days.

Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Vitamin B6 MetabolismMetabolic
HypophosphatasiaDisease
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirPyridoxine may decrease the excretion rate of Abacavir which could result in a higher serum level.
AcarbosePyridoxine may decrease the excretion rate of Acarbose which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
AcetaminophenPyridoxine may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
AclidiniumPyridoxine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
AcrivastinePyridoxine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
No interactions found.

Products

Product Ingredients
IngredientUNIICASInChI Key
Pyridoxine hydrochloride68Y4CF58BV58-56-0ZUFQODAHGAHPFQ-UHFFFAOYSA-N
Product Images
International/Other Brands
Becilan / Beesix / Benadon / Bonasanit / Hexa-Betalin / Hexobion / Nestrex
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Pyridoxine HCl Inj 100mg/mlLiquidIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada flag
Pyridoxine Hydrochloride Injection 100mg/mlSolutionIntramuscular; IntravenousHospira Healthcare Ulc1981-12-312018-09-10Canada flag
Pyridoxine Hydrochloride Injection USP 100 mg/mlSolutionIntramuscular; IntravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada flag
Pyridoxine Hydrochloride Injection, USPSolutionIntramuscular; IntravenousMylan Pharmaceuticals2002-06-01Not applicableCanada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Pyridoxine HciInjection, solution100 mg/1mLIntramuscular; IntravenousHF Acquisition Co LLC, DBA HealthFirst2019-10-08Not applicableUS flag
Pyridoxine HydrochlorideInjection, solution100 mg/1mLIntramuscular; IntravenousFresenius Kabi USA, LLC1972-08-14Not applicableUS flag
Pyridoxine HydrochlorideInjection, solution100 mg/1mLIntramuscular; IntravenousMylan Institutional LLC2016-09-012018-04-30US flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
B-6 500mg Continuous ReleasedTablet, extended releaseOralGahler Enterprises Ltd.1981-12-312007-08-07Canada flag
B-6 Caps 250mgCapsuleOralTwin Laboratories Inc.1995-12-311999-11-10Canada flag
B6 100mg Pyridoxine HClTabletOralWn Pharmaceuticals Ltd.2001-10-012009-09-28Canada flag
B6 25 Tab 25mgTabletOralLe Naturiste J.M.B. Inc.1990-12-311997-07-23Canada flag
B6 250 Caplet 250mgTabletOralHealth Wise Nutrition Inc.1996-11-131997-08-07Canada flag
B6 400mg Ctr TabTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada flag
B6 Cap 100mgCapsuleOralGahler Enterprises Ltd.1989-12-312008-07-17Canada flag
B6 Pyridoxine HCl Tab 50mgTabletOralGahler Enterprises Ltd.1984-12-312008-07-17Canada flag
B6 Tab 100mgTabletOralAlbi Naturals1979-12-312008-07-17Canada flag
B6 Tablets 100mgTabletOralGahler Enterprises Ltd.1988-12-312008-07-17Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Multivitamins + MineralsPyridoxine hydrochloride (25 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada flag
50 PlusPyridoxine hydrochloride (20 mg) + Ascorbic acid (200 mg) + Biotin (20 mcg) + Choline bitartrate (20 mg) + Cyanocobalamin (20 mcg) + Folic acid (.2 mg) + Inositol (20 mg) + Niacin (20 mg) + Calcium pantothenate (20 mg) + Racemethionine (20 mg) + Riboflavin (20 mg) + Thiamine hydrochloride (20 mg) + Vitamin A palmitate (10000 unit) + Vitamin D (400 unit) + Vitamin E (20 unit)TabletOralQuest Vitamins A Div Of Purity Life Health Products1998-08-042001-07-06Canada flag
50 Plus Multiple Vitamins & MineralsPyridoxine hydrochloride (3 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada flag
A.R.T.H. Away FormulaPyridoxine hydrochloride (0.5 mg) + Calcium (24 mg) + Cholecalciferol (45 unit) + Copper (0.232 mg) + Folic acid (0.025 mg) + Manganese (0.58 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg)CapsuleOralAbundance Naturally Ltd1999-02-012006-06-16Canada flag
Acetabolan III Vitamin and Mineral SupplementPyridoxine hydrochloride (2.63 mg) + Ascorbic acid (250.0 mg) + Magnesium (112.5 mg) + Zinc (7.5 mg)CapsuleOralIovate Health Sciences International Inc.2003-12-052007-07-18Canada flag
Acetabolan-II Vitamin and Mineral SupplementPyridoxine hydrochloride (2.1 mg) + Ascorbic acid (200 mg) + Magnesium (90 mg) + Zinc (6 mg)CapsuleOralIovate Health Sciences International Inc.2000-11-202005-06-21Canada flag
AcvPyridoxine hydrochloride (5 mg) + Chromium (150 mcg)TabletOralAbundance Naturally Ltd2001-10-012004-06-30Canada flag
Adrenogist TabPyridoxine hydrochloride (5 mg) + Pantothenic acid (100 mg) + Potassium chloride (99 mg)TabletOralPure Life International Prods Inc.1992-12-312000-07-27Canada flag
Adult Formula 50+Pyridoxine hydrochloride (6 mg) + Ascorbic acid (120 mg) + Beta carotene (3000 unit) + Biotin (30 mcg) + Calcium (220 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Iodine (0.15 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Molybdenum (10 mcg) + Nicotinamide (20 mg) + Calcium pantothenate (20 mg) + Potassium (37.5 mg) + Riboflavin (3.4 mg) + Selenium (10 mcg) + Thiamine hydrochloride (4.5 mg) + Vitamin A palmitate (3000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralWn Pharmaceuticals Ltd.2002-04-252009-09-28Canada flag
Adult Infuvite Multiple VitaminsPyridoxine hydrochloride (6 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Dexpanthenol (15 mg/10mL) + Riboflavin 5'-phosphate sodium (3.6 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL)Injection, solutionIntravenousSandoz Manufacturing Inc2005-05-18Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Active FEPyridoxine hydrochloride (20 mg/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + DL-alpha tocopheryl acetate (40 [iU]/1) + Folic acid (1250 ug/1) + Iron (75 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUS flag
Active OBPyridoxine hydrochloride (20 mg/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (2 mg/1) + Cyanocobalamin (30 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (320 mg/1) + Folic acid (1 mg/1) + Iron (20 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc oxide (30 mg/1)Capsule, liquid filledOralGm Pharmaceuticals2013-10-282017-03-31US flag
Animi-3Pyridoxine hydrochloride (12.5 mg/1) + Cholecalciferol (1000 [iU]/1) + Cyanocobalamin (500 ug/1) + Doconexent (250 mg/1) + Folic acid (1 mg/1) + Icosapent (35 mg/1) + Omega-3 fatty acids (500 mg/1) + Soy sterol (200 mg/1)CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUS flag
Animi-3 with Vitamin DPyridoxine hydrochloride (12.5 mg/1) + Cholecalciferol (1000 [iU]/1) + Cyanocobalamin (500 ug/1) + Doconexent (250 mg/1) + Folic acid (1 mg/1) + Icosapent (35 mg/1) + Omega-3 fatty acids (500 mg/1) + Soy sterol (200 mg/1)CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUS flag
Av-VITE FBPyridoxine hydrochloride (25 mg/1) + Cyanocobalamin (1 mg/1) + Folic acid (2.5 mg/1)TabletOralAv Kare, Inc.2015-11-052016-01-13US flag
B-ComboPyridoxine (1 mg/1mL) + Dexpanthenol (1 mg/1mL) + Mecobalamin (1 mg/1mL) + Nicotinamide (1 mg/1mL) + Riboflavin (1 mg/1mL) + Thiamine chloride (1 mg/1mL)InjectionIntramuscularPerdido Key Health And Wellness Inc2015-11-23Not applicableUS flag
B-NexaPyridoxine (42 mg/1) + Calcium (124.23 mg/1) + Folic acid (1.22 mg/1) + Ginger (100 mg/1)TabletOralUpsher Smith Laboratories2012-08-152015-04-30US flag
B-NexaPyridoxine (40 mg/1) + Calcium (124.1 mg/1) + Folic acid (1.2 mg/1) + Ginger (100 mg/1)TabletOralUpsher Smith Laboratories2011-12-082014-02-28US flag
B-plex 100Pyridoxine hydrochloride (2 mg/1mL) + Dexpanthenol (2 mg/1mL) + Riboflavin 5'-phosphate sodium (2 mg/1mL) + Nicotinamide (100 mg/1mL) + Thiamine hydrochloride (100 mg/1mL)Injection, solutionIntramuscular; IntravenousMerit Pharmaceutical2012-01-01Not applicableUS flag
BacminPyridoxine hydrochloride (25 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Manganese gluconate (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)Tablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUS flag

Categories

ATC Codes
J04AM08 — Isoniazid, sulfamethoxazole, trimethoprim and pyridoxineA11HA02 — Pyridoxine (vit b6)
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as pyridoxines. These are pyridoxal derivatives in which the carbaldehyde group at position 2 of the pyridoxal moiety is replaced by a hydroxymethyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Pyridoxines
Direct Parent
Pyridoxines
Alternative Parents
Methylpyridines / Hydroxypyridines / Heteroaromatic compounds / Azacyclic compounds / Primary alcohols / Organopnictogen compounds / Organonitrogen compounds / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Alcohol / Aromatic alcohol / Aromatic heteromonocyclic compound / Azacycle / Heteroaromatic compound / Hydrocarbon derivative / Hydroxypyridine / Methylpyridine / Organic nitrogen compound / Organic oxygen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
monohydroxypyridine, methylpyridines, vitamin B6, hydroxymethylpyridine (CHEBI:16709) / Water-soluble vitamins (C00314) / a vitamin B6 (PYRIDOXINE)

Chemical Identifiers

UNII
KV2JZ1BI6Z
CAS number
65-23-6
InChI Key
LXNHXLLTXMVWPM-UHFFFAOYSA-N
InChI
InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
IUPAC Name
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
SMILES
CC1=C(O)C(CO)=C(CO)C=N1

References

Synthesis Reference

Harumi Kita, "Production of pyridoxine." U.S. Patent US4339586, issued October, 1972.

US4339586
General References
  1. Sang Y, Barbosa JM, Wu H, Locy RD, Singh NK: Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana. FEBS Lett. 2007 Feb 6;581(3):344-8. doi: 10.1016/j.febslet.2006.12.028. Epub 2007 Jan 3. [PubMed:17224143]
  2. Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB: Vitamin B6 biosynthesis in higher plants. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13687-92. doi: 10.1073/pnas.0506228102. Epub 2005 Sep 12. [PubMed:16157873]
  3. Cohen M, Bendich A: Safety of pyridoxine--a review of human and animal studies. Toxicol Lett. 1986 Dec;34(2-3):129-39. doi: 10.1016/0378-4274(86)90202-x. [PubMed:3541289]
  4. DailyMed: Pyridoxine hydrochloride tablets [Link]
  5. FDA Approved Products: Diclegis (doxylamine succinate and pyridoxine hydrochloride) [Link]
  6. Vitamin B6: Health professionals fact sheet [Link]
  7. Pyridoxine, DailyMed [Link]
Human Metabolome Database
HMDB0000239
KEGG Compound
C00314
PubChem Compound
1054
PubChem Substance
46508560
ChemSpider
1025
BindingDB
50103505
RxNav
42954
ChEBI
16709
ChEMBL
CHEMBL1364
ZINC
ZINC000000049154
Therapeutic Targets Database
DAP000869
PharmGKB
PA451897
PDBe Ligand
UEG
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Pyridoxine
AHFS Codes
  • 88:08.00 — Vitamin B Complex
PDB Entries
4c5l / 4c5n / 5eb3 / 6k91
FDA label
Download (516 KB)
MSDS
Download (51.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingOtherAlcohol Abuse / Human Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS) / Tuberculosis (TB)1
4Active Not RecruitingTreatmentCardiopulmonary Bypass / Congenital Heart Disease (CHD) / Thiamine Deficiency1
4CompletedPreventionDyslipidemia / Homocystinaemia / Menopause1
4CompletedPreventionVincristine Induced Peripheral Neuropathy (VIPN)1
4CompletedTreatmentAcute Schizophrenia1
4CompletedTreatmentDiabetic Macular Edema (DME)1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain (DPN)1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
4RecruitingTreatmentAnemia, Pernicious / Megaloblastic Anemia Nos1

Pharmacoeconomics

Manufacturers
  • Eli lilly and co
  • Akorn inc
  • App pharmaceuticals llc
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Elkins sinn div ah robins co inc
  • Luitpold pharmaceuticals inc
  • Watson laboratories inc
Packagers
  • Accucaps Industries Ltd.
  • Alaven Pharmaceutical
  • Allan Pharmaceutical LLC
  • APP Pharmaceuticals
  • Breckenridge Pharmaceuticals
  • Carlisle Laboratories Inc.
  • Chemins Co. Inc.
  • Consolidated Midland Corp.
  • Contract Pharm
  • CVS Pharmacy
  • Darby Dental Supply Co. Inc.
  • Diversified Healthcare Services Inc.
  • Everett Laboratories Inc.
  • Heartland Repack Services LLC
  • Ivax Pharmaceuticals
  • J T Baker
  • Key Co.
  • KV Pharmaceutical Co.
  • Larken Laboratories Inc.
  • Martica Enterprises Inc.
  • Martin Surgical Supply
  • Mason Distributors
  • Midlothian Labs
  • Murfreesboro Pharmaceutical Nursing Supply
  • Nexgen Pharma Inc.
  • Pamlab LLC
  • Particle Dynamics Co.
  • Patheon Inc.
  • Perrigo Co.
  • Pharmetics Inc.
  • Phoenix Labs Rising LLC
  • Physicians Total Care Inc.
  • PlusPharma Inc.
  • Prescript Pharmaceuticals
  • Primedics Laboratories
  • Provident Pharmaceuticals LLC
  • Puretek Corp.
  • Red River Pharma Manufacturing
  • Respa Pharmaceuticals Inc.
  • Rising Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Rugby Laboratories
  • Sciele Pharma Inc.
  • SJ Pharmaceuticals LLC
  • Upsher Smith Laboratories
  • US Pharmaceutical Corp.
  • Walgreen Co.
  • Zylera Pharmaceuticals LLC
Dosage Forms
FormRouteStrength
ElixirOral
Capsule; liquidOral
SolutionIntramuscular1000 mcg
TabletOral250 mg
Tablet, delayed releaseOral250 mg
Bar, chewableOral
Solution250 mg
Tablet50 mg
Tablet, extended releaseOral
SolutionIntramuscular; Intravenous25 mg/2ml
PatchTransdermal
Capsule, liquid filledOral50 mg
Tablet40 mg
Tablet, sugar coatedOral300 MG
Tablet, coated15 mg
SyrupOral5 mg/5ml
Tablet250 mg
Tablet, delayed release250 mg
Solution2.5 mg/ml
Tablet, coated25 mg
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
Tablet, coatedOral250 mg
Tablet, extended releaseOral
SolutionOral50 mg
Tablet, coatedOral20 mg
SolutionIntramuscular10 mg
SolutionIntramuscular50 mg
Tablet, coatedOral50 mg
SolutionIntramuscular300 mg
Capsule, liquid filledOral
CapsuleOral
Tablet, film coated8000 IU
Tablet4000 IU
Capsule4000 IU
SprayTopical
Tablet, delayed releaseOral
Paste, dentifriceTopical
Tablet, effervescentOral
TabletOral4000 IU
LiquidOral
Tablet15 mg
SyrupOral20 mg/5ml
LozengeOral
LiquidIntramuscular; Intravenous
Capsule, delayed releaseOral0.6 mg
SyrupOral0.3443 g
SyrupOral1 g
ElixirOral195 mg
Tablet, coatedOral150 mcg
Tablet, coatedOral
TabletOral100 mg
PatchTopical
Tablet, coatedOral15 mg
Injection, solutionIntramuscular; Intravenous300 mg/2ml
Injection300 mg/2mL
InjectionIntramuscular
Lozenge20 mg
Injection, powder, lyophilized, for solutionIntravenous
KitIntravenous
CreamTopical
SolutionOral10 mg
LiquidTopical
SolutionIntravenous
Tablet, chewableOral
SolutionIntravenous140 mcg
SolutionOral
Capsule, liquid filledOral0.25 mg
TabletOral
LiquidIntravenous
Capsule, liquid filledOral0.6 mg
SolutionIntramuscular; Intravenous
Tablet, orally disintegratingOral
Tablet, sugar coatedOral250 mg
Tablet, sugar coatedOral100 mg
Tablet, film coatedOral100 mg
Tablet, coatedOral150 mg
SolutionIntramuscular100 mg
InjectionParenteral25000 mcg
Injection, solutionParenteral25 MG
Tablet, film coatedOral10 mg
Capsule, delayed releaseOral150 mg
SyrupOral
Injection, solutionIntravenous
SolutionOral100 mg
PasteDental
TabletOral50 mg
Capsule, delayed releaseOral10 mg
Suspension / dropsOral
Solution / dropsOral
Tablet, delayed releaseOral10 mg
Tablet, film coatedOral
Capsule, liquid filledOral0.1 mg
Capsule, gelatin coatedOral
Tablet, delayed release10 mg
PillOral
LiquidIntramuscular; Intravenous
Injection, solutionIntramuscular; Intravenous100 mg/1mL
TabletOral25 mg/1
TabletOral50 mg/1
SolutionIntramuscular; Intravenous
WaferOral
Syrup1250 IU
Syrup150 ml
Solution2.5 mg
Liquid; tabletOral
Powder, for solutionOral
Capsule, liquid filledOral1 mg
Tablet
Capsule, extended releaseOral
Powder, for solution3500 IU
Capsule, coatedOral
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous3500 IU
SolutionIntravenous5 g
CapsuleOral3.5 mg
Tablet, chewableOral5000 IU
Injection, solution200 mg
Injection, solution250 mg
Injection, solution50 mg
Capsule, liquid filledOral25 mg
CapsuleOral
TabletOral15 mg
SyrupOral1250 IU/5mL
StripOral
Tablet20 MG
InjectionIntramuscular; Intravenous
InjectionIntravenous
Injection, solutionIntramuscular; Intravenous
Tablet100 mg
Tablet, film coatedOral40 MG
TabletOral
SyrupOral320 mg
KitOral
PowderOral
TabletOral200 mg
Tablet, film coatedOral200 mg
GranuleOral70 mcg
Prices
Unit descriptionCostUnit
Pyridoxine HCl 100 50 mg tablet Bottle12.99USD bottle
Pyridoxine HCl 100 mg/ml vial11.69USD vial
Pyridoxine 100 mg/ml vial10.79USD ml
Pyridoxine hcl crystals6.94USD g
Pyridoxine 500 mg tablet0.18USD tablet
Pyridoxine 25 mg tablet0.14USD tablet
Neuro k 500 mg tablet0.13USD tablet
Pyridoxine 250 mg tablet0.13USD tablet
CVS Pharmacy vitamin b-6 200 mg tablet0.07USD tablet
Neuro-k 250 mg tablet0.06USD tablet
Pyridoxine 50 mg tablet0.06USD tablet
Vitamin b-6 100 mg tablet0.04USD tablet
CVS Pharmacy vitamin b-6 100 mg tablet0.03USD tablet
Pyridoxine 100 mg tablet0.03USD tablet
Vitamin b6 50 mg tablet0.03USD tablet
Vitamin b-6 50 mg tablet0.03USD tablet
CVS Pharmacy vitamin b-6 50 mg tablet0.02USD tablet
Vitamin b-6 25 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6340695No2002-01-222021-06-21US flag
US7560122No2009-07-142019-01-25US flag
US9526703No2016-12-272033-02-18US flag
US9375404No2016-06-282033-02-18US flag
US9089489No2015-07-282033-02-18US flag
US9937132No2018-04-102033-02-18US flag
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)159-162 °CPhysProp
water solubility2.2E+005 mg/LNot Available
logP-0.77SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility16.1 mg/mLALOGPS
logP-0.57ALOGPS
logP-0.95ChemAxon
logS-1ALOGPS
pKa (Strongest Acidic)9.4ChemAxon
pKa (Strongest Basic)5.58ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area73.58 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity44.11 m3·mol-1ChemAxon
Polarizability17.11 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9728
Blood Brain Barrier+0.6889
Caco-2 permeable-0.8958
P-glycoprotein substrateNon-substrate0.5579
P-glycoprotein inhibitor INon-inhibitor0.9723
P-glycoprotein inhibitor IINon-inhibitor0.9221
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.7386
CYP450 2D6 substrateNon-substrate0.781
CYP450 3A4 substrateNon-substrate0.7104
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8648
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.695
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9418
BiodegradationNot ready biodegradable0.5678
Rat acute toxicity1.6573 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8454
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-000t-0940000000-30b4702623a6d8fcb4bb
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)GC-MSsplash10-001j-0690000000-0581e2b42fa48c1ea498
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-9330000000-32929ff06762b9f5887f
GC-MS Spectrum - GC-MS (3 TMS)GC-MSsplash10-001i-0490000000-34a09ddbbb462aeb02a6
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0f6x-9400000000-486db54a30b61c2eb9d4
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-000t-0940000000-30b4702623a6d8fcb4bb
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-001j-0690000000-0581e2b42fa48c1ea498
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9330000000-32929ff06762b9f5887f
GC-MS Spectrum - GC-MSGC-MSsplash10-001i-0490000000-34a09ddbbb462aeb02a6
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-001j-0790000000-6f8f6e679e03f9119a65
Mass Spectrum (Electron Ionization)MSsplash10-1003-6900000000-1237eaf82dfadfd54d4b
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-0vi0-0900000000-bd0de86c072765a5caad
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-001i-3900000000-2018b406a3c75213b733
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-0059-9200000000-e69bb531deb2a103a476
MS/MS Spectrum - EI-B (HITACHI M-80) , PositiveLC-MS/MSsplash10-0f6x-9400000000-77c43a946c4ae1abf3b9
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, NegativeLC-MS/MSsplash10-014i-0900000000-479d4492cc8d634fa366
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, NegativeLC-MS/MSsplash10-0udi-0900000000-486d6a4e5e1a731b7c54
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, NegativeLC-MS/MSsplash10-05fr-0900000000-4ef09ce9c04561a1085e
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, NegativeLC-MS/MSsplash10-0ab9-1900000000-3298adf6db36689d5d43
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, NegativeLC-MS/MSsplash10-0a6r-7900000000-6711954ee96f08344434
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, PositiveLC-MS/MSsplash10-00di-0900000000-234e90d43a7febd7a098
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, PositiveLC-MS/MSsplash10-0udi-0900000000-137080765c0035b45258
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, PositiveLC-MS/MSsplash10-001i-0900000000-882ee900a8bba08e2c7c
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, PositiveLC-MS/MSsplash10-003r-8900000000-e0e11797b63cea991d81
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, PositiveLC-MS/MSsplash10-0059-9100000000-c25384179219411af02c
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , PositiveLC-MS/MSsplash10-0ue9-0900000000-c0e149ce890192397b7f
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , NegativeLC-MS/MSsplash10-0v4i-0900000000-f9f378af3d47ab006806
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0uk9-0900000000-eab5b3411261744df750
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0ue9-0900000000-cc4dc8719602182ef1eb
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-5900000000-1c2637733578fcdd7c6a
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0900000000-e89cc69d8b21012ff982
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-059i-0900000000-0ad8d09e042015cb2e33
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9500000000-577a3d87899ca47d539f
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-014i-0900000000-479d4492cc8d634fa366
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0udi-0900000000-486d6a4e5e1a731b7c54
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-05fr-0900000000-4ef09ce9c04561a1085e
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0ab9-1900000000-3298adf6db36689d5d43
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0a6r-7900000000-6711954ee96f08344434
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0v4i-0900000000-f9f378af3d47ab006806
MS/MS Spectrum - , negativeLC-MS/MSsplash10-0uxr-0900000000-dd61975d762fdc6e1e95
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-00di-0900000000-234e90d43a7febd7a098
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0udi-0900000000-137080765c0035b45258
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-0900000000-882ee900a8bba08e2c7c
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-003r-8900000000-ffea92733494372f905d
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0059-9100000000-ef6ae8502e892d6053f0
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0ue9-0900000000-c0e149ce890192397b7f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0900000000-99bef4a72e90ec8f7ea6
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Ligand
General Function
Zinc ion binding
Specific Function
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name
PDXK
Uniprot ID
O00764
Uniprot Name
Pyridoxal kinase
Molecular Weight
35102.105 Da
References
  1. Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. [PubMed:16494569]
  2. Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12. [PubMed:16978644]
  3. Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83. [PubMed:16466641]
  4. Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7. [PubMed:18256491]
  5. Musayev FN, di Salvo ML, Ko TP, Gandhi AK, Goswami A, Schirch V, Safo MK: Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. Protein Sci. 2007 Oct;16(10):2184-94. doi: 10.1110/ps.073022107. Epub 2007 Aug 31. [PubMed:17766369]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Inhibitor
Curator comments
These data have been found in mouse animal model studies. Relevance to humans is unknown.
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Tangjarukij C, Navasumrit P, Zelikoff JT, Ruchirawat M: The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. J Immunotoxicol. 2009 Sep;6(3):147-60. doi: 10.1080/15476910903083866. [PubMed:19637937]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Zinc ion binding
Specific Function
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name
PDXK
Uniprot ID
O00764
Uniprot Name
Pyridoxal kinase
Molecular Weight
35102.105 Da
References
  1. Merrill AH Jr, Henderson JM: Vitamin B6 metabolism by human liver. Ann N Y Acad Sci. 1990;585:110-7. doi: 10.1111/j.1749-6632.1990.tb28047.x. [PubMed:2192606]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Pyridoxal phosphatase activity
Specific Function
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization...
Gene Name
PDXP
Uniprot ID
Q96GD0
Uniprot Name
Pyridoxal phosphate phosphatase
Molecular Weight
31697.735 Da
References
  1. Merrill AH Jr, Henderson JM: Vitamin B6 metabolism by human liver. Ann N Y Acad Sci. 1990;585:110-7. doi: 10.1111/j.1749-6632.1990.tb28047.x. [PubMed:2192606]
  2. Coburn SP: Vitamin B-6 Metabolism and Interactions with TNAP. Subcell Biochem. 2015;76:207-38. doi: 10.1007/978-94-017-7197-9_11. [PubMed:26219714]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Pyrophosphatase activity
Specific Function
This isozyme may play a role in skeletal mineralization.
Gene Name
ALPL
Uniprot ID
P05186
Uniprot Name
Alkaline phosphatase, tissue-nonspecific isozyme
Molecular Weight
57304.435 Da
References
  1. Whyte MP, Mahuren JD, Vrabel LA, Coburn SP: Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism. J Clin Invest. 1985 Aug;76(2):752-6. doi: 10.1172/JCI112031. [PubMed:4031070]
  2. Ueland PM, Ulvik A, Rios-Avila L, Midttun O, Gregory JF: Direct and Functional Biomarkers of Vitamin B6 Status. Annu Rev Nutr. 2015;35:33-70. doi: 10.1146/annurev-nutr-071714-034330. Epub 2015 May 13. [PubMed:25974692]

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Parra M, Stahl S, Hellmann H: Vitamin B(6) and Its Role in Cell Metabolism and Physiology. Cells. 2018 Jul 22;7(7). pii: cells7070084. doi: 10.3390/cells7070084. [PubMed:30037155]
  2. Fonda ML, Trauss C, Guempel UM: The binding of pyridoxal 5'-phosphate to human serum albumin. Arch Biochem Biophys. 1991 Jul;288(1):79-86. doi: 10.1016/0003-9861(91)90167-h. [PubMed:1898027]

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Pyrophosphatase activity
Specific Function
This isozyme may play a role in skeletal mineralization.
Gene Name
ALPL
Uniprot ID
P05186
Uniprot Name
Alkaline phosphatase, tissue-nonspecific isozyme
Molecular Weight
57304.435 Da
References
  1. Coburn SP: Vitamin B-6 Metabolism and Interactions with TNAP. Subcell Biochem. 2015;76:207-38. doi: 10.1007/978-94-017-7197-9_11. [PubMed:26219714]
  2. Whyte MP, Mahuren JD, Vrabel LA, Coburn SP: Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism. J Clin Invest. 1985 Aug;76(2):752-6. doi: 10.1172/JCI112031. [PubMed:4031070]

Drug created on June 13, 2005 07:24 / Updated on September 17, 2020 23:29

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