Alanine--tRNA ligase, cytoplasmic

BE0000294ProteinHumansAARS1

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). It is acted on by 1 drug in DrugBank.

Gene name
AARS1
UniProtKB entry
P49588Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
968 residues · 106,810 Da
Also known as
6.1.1.7 · AARS · Alanyl-tRNA synthetase · AlaRS · Protein lactyltransferase AARS1

Resolves to

Protein
UniProtP49588UniProt nameSYAC_HUMAN
Gene
HGNCHGNC:20NCBI Gene16GenBank1015321GeneCardsAARS1
Pharmacology
KEGGhsa:16
Structure
PDB4XEMPDB4XEOPDB5KNN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Alanine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In