Sorbitol dehydrogenase

BE0000299ProteinHumansSORD

Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. It is acted on by 3 drugs in DrugBank.

Gene name
SORD
UniProtKB entry
Q00796Swiss-Prot
Cellular location
Mitochondrion membrane
Residues / weight
357 residues · 38,324 Da
Also known as
(R,R)-butanediol dehydrogenase · 1.1.1.- · L-iditol 2-dehydrogenase · Polyol dehydrogenase · RDH

Resolves to

Protein
UniProtQ00796UniProt nameDHSO_HUMAN
Gene
HGNCHGNC:11184NCBI Gene6652GenBank520450GeneCardsSORD
Pharmacology
KEGGhsa:6652
Structure
PDB1PL6PDB1PL7PDB1PL8
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sorbitol dehydrogenase, how selective are they, and which programs against it are still in active trials?

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