Spermidine synthase

BE0000300ProteinHumansSRM

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). It is acted on by 1 drug in DrugBank.

Gene name
SRM
UniProtKB entry
P19623Swiss-Prot
Residues / weight
302 residues · 33,824 Da
Also known as
2.5.1.16 · Putrescine aminopropyltransferase · SPDSY · SPS1 · SRML1

Resolves to

Protein
UniProtP19623UniProt nameSPEE_HUMAN
Gene
HGNCHGNC:11296NCBI Gene6723GenBank531202GeneCardsSRM
Pharmacology
KEGGhsa:6723
Structure
PDB2O05PDB2O06PDB2O07
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Spermidine synthase, how selective are they, and which programs against it are still in active trials?

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