Ornithine transcarbamylase, mitochondrial

BE0000306ProteinHumansOTC

Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:2556444, PubMed:6372096, PubMed:8112735). It is acted on by 4 drugs in DrugBank.

Gene name
OTC
UniProtKB entry
P00480Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
354 residues · 39,935 Da
Also known as
2.1.3.3 · Ornithine carbamoyltransferase, mitochondrial · OTCase

Resolves to

Protein
UniProtP00480UniProt nameOTC_HUMAN
Gene
HGNCHGNC:8512NCBI Gene5009GenBank189407GeneCardsOTC
Pharmacology
KEGGhsa:5009
Structure
PDB1C9YPDB1EP9PDB1FVO
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ornithine transcarbamylase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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