Norvaline
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Identification
- Summary
Norvaline is a drug used to treat vaginal inflammation with betamethasone and tyrothricin.
- Generic Name
- Norvaline
- DrugBank Accession Number
- DB04185
- Background
Norvaline is an isomer of the more common amino acid valine.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 117.1463
Monoisotopic: 117.078978601 - Chemical Formula
- C5H11NO2
- Synonyms
- (S)-2-Aminopentanoic acid
- 2-Aminopentanoic acid
- 2-Aminovaleric acid
- L-2-aminopentanoic acid
- L-2-Aminovaleric acid
- L-Norvaline
- External IDs
- NSC-203786
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Vaginal inflammation Combination Product in combination with: Tyrothricin (DB13503), Betamethasone (DB00443), Norvaline (DB04185) •••••••••••• •••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UGlycine amidinotransferase, mitochondrial Not Available Humans UOrnithine carbamoyltransferase, mitochondrial Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DELTAVAGIN Norvaline (100 mg) + Betamethasone (2 mg) + Tyrothricin (10 mg) Insert Vaginal Farmitalia Industria Chimico Farmaceutica S.R.L. 2014-07-08 Not applicable Italy DELTAVAGIN Norvaline (100 mg) + Betamethasone (2 mg) + Tyrothricin (10 mg) Insert Vaginal Farmitalia Industria Chimico Farmaceutica S.R.L. 2014-07-08 2022-02-16 Italy DELTAVAGIN Norvaline (100 mg) + Betamethasone (2 mg) + Tyrothricin (10 mg) Insert Vaginal Farmitalia Industria Chimico Farmaceutica S.R.L. 2014-07-08 2022-02-16 Italy
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- L-alpha-amino acids
- Alternative Parents
- Methyl-branched fatty acids / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Amine / Amino acid / Branched fatty acid / Carbonyl group / Carboxylic acid / Fatty acid / Fatty acyl / Hydrocarbon derivative / L-alpha-amino acid
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- 2-aminopentanoic acid, (R)-fenbuconazole (CHEBI:18314) / Amino fatty acids (C01826) / Amino fatty acids (LMFA01100041)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- A70UKS48FE
- CAS number
- 6600-40-4
- InChI Key
- SNDPXSYFESPGGJ-BYPYZUCNSA-N
- InChI
- InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
- IUPAC Name
- (2S)-2-aminopentanoic acid
- SMILES
- CCC[C@H](N)C(O)=O
References
- Synthesis Reference
Naoyuki Harada, Masataka Hikota, "Norvaline Derivative and Method for Preparation Thereof." U.S. Patent US20080076769, issued March 27, 2008.
US20080076769- General References
- Not Available
- External Links
- KEGG Compound
- C01826
- PubChem Compound
- 65098
- PubChem Substance
- 46507762
- ChemSpider
- 58608
- BindingDB
- 50357215
- ChEBI
- 18314
- ChEMBL
- CHEMBL55612
- ZINC
- ZINC000000391821
- PDBe Ligand
- NVA
- Wikipedia
- Norvaline
- PDB Entries
- 1b6h / 1c9y / 1fb5 / 1jdx / 1obc / 1obh / 1z3m / 1z3p / 1znm / 2bte … show 15 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Insert Vaginal - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 212.0 mg/mL ALOGPS logP -2 ALOGPS logP -1.9 Chemaxon logS 0.26 ALOGPS pKa (Strongest Acidic) 2.71 Chemaxon pKa (Strongest Basic) 9.53 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 29.62 m3·mol-1 Chemaxon Polarizability 12.51 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 122.6187618 predictedDarkChem Lite v0.1.0 [M-H]- 123.15447 predictedDeepCCS 1.0 (2019) [M+H]+ 123.3455618 predictedDarkChem Lite v0.1.0 [M+H]+ 125.97095 predictedDeepCCS 1.0 (2019) [M+Na]+ 122.6319618 predictedDarkChem Lite v0.1.0 [M+Na]+ 134.57912 predictedDeepCCS 1.0 (2019)
Targets
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Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Glycine amidinotransferase activity
- Specific Function
- Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central ner...
- Gene Name
- GATM
- Uniprot ID
- P50440
- Uniprot Name
- Glycine amidinotransferase, mitochondrial
- Molecular Weight
- 48455.01 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phospholipid binding
- Specific Function
- Not Available
- Gene Name
- OTC
- Uniprot ID
- P00480
- Uniprot Name
- Ornithine carbamoyltransferase, mitochondrial
- Molecular Weight
- 39934.775 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at June 13, 2005 13:24 / Updated at June 09, 2021 08:40