NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

BE0000307ProteinHumansNDUFS7

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:17275378). It is acted on by 3 drugs in DrugBank.

Gene name
NDUFS7
UniProtKB entry
O75251Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
213 residues · 23,563 Da
Also known as
7.1.1.2 · CI-20kD · Complex I-20kD · NADH-ubiquinone oxidoreductase 20 kDa subunit · PSST subunit

Resolves to

Protein
UniProtO75251UniProt nameNDUS7_HUMAN
Gene
HGNCHGNC:7714NCBI Gene374291GenBank3342734GeneCardsNDUFS7
Pharmacology
KEGGhsa:374291
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, how selective are they, and which programs against it are still in active trials?

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