Apoptotic protease-activating factor 1

BE0000310ProteinHumansAPAF1

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. It is acted on by 2 drugs in DrugBank.

Gene name
APAF1
UniProtKB entry
O14727Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,248 residues · 141,839 Da
Also known as
APAF-1 · KIAA0413

Resolves to

Protein
UniProtO14727UniProt nameAPAF_HUMAN
Gene
HGNCHGNC:576NCBI Gene317GenBank2330015GeneCardsAPAF1
Pharmacology
KEGGhsa:317
Structure
PDB1C15PDB1CWWPDB1CY5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Apoptotic protease-activating factor 1, and which indications are they being tested in?

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