Methylmalonic aciduria type A protein, mitochondrial

BE0000320ProteinHumansMMAA

GTPase, binds and hydrolyzes GTP (PubMed:20876572, PubMed:21138732, PubMed:28497574, PubMed:28943303). It is acted on by 2 drugs in DrugBank.

Gene name
MMAA
UniProtKB entry
Q8IVH4Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
418 residues · 46,538 Da
Also known as
3.6.-.-

Resolves to

Protein
UniProtQ8IVH4UniProt nameMMAA_HUMAN
Gene
HGNCHGNC:18871NCBI Gene166785GenBank26006421GeneCardsMMAA
Pharmacology
KEGGhsa:166785
Structure
PDB2WWWPDB8GJU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylmalonic aciduria type A protein, mitochondrial, how selective are they, and which programs against it are still in active trials?

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