Serine hydroxymethyltransferase, cytosolic

BE0000331ProteinHumansSHMT1

Pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF, serving as a critical component of the folate cycle and facilitating one-carbon biosynthetic reactions essential for... It is acted on by 7 drugs in DrugBank.

Gene name
SHMT1
UniProtKB entry
P34896Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
483 residues · 53,082 Da
Also known as
2.1.2.1 · cSHMT · Glycine hydroxymethyltransferase · hcSHMT · L-allo-threonine/L-threonine aldolase SHMT1

Resolves to

Protein
UniProtP34896UniProt nameGLYC_HUMAN
Gene
HGNCHGNC:10850NCBI Gene6470GenBank307422GeneCardsSHMT1
Pharmacology
KEGGhsa:6470
Structure
PDB1BJ4PDB6FL5PDB6M5W
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine hydroxymethyltransferase, cytosolic, how selective are they, and which programs against it are still in active trials?

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