17-beta-hydroxysteroid dehydrogenase type 3

BE0000336ProteinHumansHSD17B3

Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:16216911, PubMed:23856005, PubMed:26545797, PubMed:27927697, PubMed:8075637). It is acted on by 2 drugs in DrugBank.

Gene name
HSD17B3
UniProtKB entry
P37058Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
310 residues · 34,515 Da
Also known as
17-beta-HSD 3 · EDH17B3 · Estradiol 17-beta-dehydrogenase 2 · SDR12C2 · Short chain dehydrogenase/reductase family 12C member 2

Resolves to

Protein
UniProtP37058UniProt nameDHB3_HUMAN
Gene
HGNCHGNC:5212NCBI Gene3293GenBank531162GeneCardsHSD17B3
Pharmacology
KEGGhsa:3293
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 17-beta-hydroxysteroid dehydrogenase type 3, how selective are they, and which programs against it are still in active trials?

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