G protein-coupled receptor kinase 2

BE0000341ProteinHumansGRK2

Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed:19715378, PubMed:21799898, PubMed:23077507, PubMed:30284927, PubMed:33859231, PubMed:39138140, PubMed:40384633). It is acted on by 1 drug in DrugBank.

Gene name
GRK2
UniProtKB entry
P25098Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
689 residues · 79,573 Da
Also known as
2.7.11.16 · ADRBK1 · BARK · BARK1 · Beta-adrenergic receptor kinase 1

Resolves to

Protein
UniProtP25098UniProt nameGRK2_HUMAN
Gene
HGNCHGNC:289NCBI Gene156GenBank288308GeneCardsGRK2
Pharmacology
IUPHAR/GtoPdb1466KEGGhsa:156
Structure
PDB1BAKPDB3CIKPDB3KRW
Drugs

What you can answer from here — as of June 19, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on G protein-coupled receptor kinase 2, and which indications are they being tested in?

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